BRD-K67619794_2,6-difluoro-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzamide_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K67619794_2,6-difluoro-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzamide_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOB aldolase B, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
AUTS2 autism susceptibility candidate 2
BLNK B-cell linker
CA9 carbonic anhydrase IX
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD79A CD79a molecule, immunoglobulin-associated alpha
CECR1 cat eye syndrome chromosome region, candidate 1
CLC Charcot-Leyden crystal galectin
CRABP2 cellular retinoic acid binding protein 2
DEFA5 defensin, alpha 5, Paneth cell-specific
DENND1B DENN/MADD domain containing 1B
FABP6 fatty acid binding protein 6, ileal
FCGBP Fc fragment of IgG binding protein
FRY furry homolog (Drosophila)
GUSBP11 glucuronidase, beta pseudogene 11
HBD hemoglobin, delta
HIST1H2BG histone cluster 1, H2bg
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IPO13 importin 13
JUN jun proto-oncogene
MZB1 marginal zone B and B1 cell-specific protein
NCAM1 neural cell adhesion molecule 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NELL2 NEL-like 2 (chicken)
PLEK2 pleckstrin 2
POU2AF1 POU class 2 associating factor 1
PRSS2 protease, serine, 2 (trypsin 2)
PRUNE2 prune homolog 2 (Drosophila)
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RNF130 ring finger protein 130
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SFRP1 secreted frizzled-related protein 1
SMC1A structural maintenance of chromosomes 1A
SPON2 spondin 2, extracellular matrix protein
SPRR3 small proline-rich protein 3
STC1 stanniocalcin 1
TFF1 trefoil factor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB2 tribbles pseudokinase 2
TXNIP thioredoxin interacting protein
UBQLN2 ubiquilin 2
VEGFA vascular endothelial growth factor A
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAM9 ADAM metallopeptidase domain 9
ADI1 acireductone dioxygenase 1
ADIPOQ adiponectin, C1Q and collagen domain containing
AHR aryl hydrocarbon receptor
ANXA7 annexin A7
AREG amphiregulin
ATF1 activating transcription factor 1
BET1 Bet1 golgi vesicular membrane trafficking protein
C3 complement component 3
C5ORF22 chromosome 5 open reading frame 22
C5ORF28 chromosome 5 open reading frame 28
C8ORF4 chromosome 8 open reading frame 4
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CETN3 centrin, EF-hand protein, 3
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL14 chemokine (C-X-C motif) ligand 14
CYCS cytochrome c, somatic
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
DOCK4 dedicator of cytokinesis 4
DST dystonin
DUSP10 dual specificity phosphatase 10
DYNLT3 dynein, light chain, Tctex-type 3
EBNA1BP2 EBNA1 binding protein 2
EDN1 endothelin 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EREG epiregulin
ETNK1 ethanolamine kinase 1
FADS3 fatty acid desaturase 3
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FOSL2 FOS-like antigen 2
FZD6 frizzled class receptor 6
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GDF15 growth differentiation factor 15
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLTF helicase-like transcription factor
HOXB7 homeobox B7
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IL18 interleukin 18
ITGAV integrin, alpha V
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LY75 lymphocyte antigen 75
LYPLA1 lysophospholipase I
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MET MET proto-oncogene, receptor tyrosine kinase
MYO6 myosin VI
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
NNT nicotinamide nucleotide transhydrogenase
NOV nephroblastoma overexpressed
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRIP1 nuclear receptor interacting protein 1
OXCT1 3-oxoacid CoA transferase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHF20 PHD finger protein 20
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPA1 pyrophosphatase (inorganic) 1
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RBM7 RNA binding motif protein 7
RECQL RecQ helicase-like
RFK riboflavin kinase
RGS1 regulator of G-protein signaling 1
S100A2 S100 calcium binding protein A2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SMNDC1 survival motor neuron domain containing 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SYNM synemin, intermediate filament protein
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFAM transcription factor A, mitochondrial
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN3 tetraspanin 3
TXNDC9 thioredoxin domain containing 9
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP22 ubiquitin specific peptidase 22
WBP5 WW domain binding protein 5