BRD-K67100011_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

114 genes differentially expressed following the BRD-K67100011_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ANGPTL2 angiopoietin-like 2
ANXA1 annexin A1
CA2 carbonic anhydrase II
CAPN2 calpain 2, (m/II) large subunit
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
CLCA4 chloride channel accessory 4
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CTBP2 C-terminal binding protein 2
CTSK cathepsin K
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
DCN decorin
DUOX2 dual oxidase 2
FBN2 fibrillin 2
GMPR guanosine monophosphate reductase
GPRC5B G protein-coupled receptor, class C, group 5, member B
HBD hemoglobin, delta
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN4 high mobility group nucleosomal binding domain 4
IGFBP5 insulin-like growth factor binding protein 5
KIAA1462 KIAA1462
LDOC1 leucine zipper, down-regulated in cancer 1
LTBP1 latent transforming growth factor beta binding protein 1
MAOA monoamine oxidase A
MECOM MDS1 and EVI1 complex locus
MME membrane metallo-endopeptidase
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYOF myoferlin
NEB nebulin
NOX4 NADPH oxidase 4
P3H2 prolyl 3-hydroxylase 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAGE4 P antigen family, member 4 (prostate associated)
PDE4B phosphodiesterase 4B, cAMP-specific
PFKM phosphofructokinase, muscle
PLBD1 phospholipase B domain containing 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
POSTN periostin, osteoblast specific factor
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCI protein kinase C, iota
RCAN2 regulator of calcineurin 2
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
TCF4 transcription factor 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPM2 tropomyosin 2 (beta)
TRIB2 tribbles pseudokinase 2
TRIM22 tripartite motif containing 22
TRPS1 trichorhinophalangeal syndrome I
TWIST1 twist family bHLH transcription factor 1
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
AFP alpha-fetoprotein
APOC2 apolipoprotein C-II
APOE apolipoprotein E
AQP3 aquaporin 3 (Gill blood group)
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BEX1 brain expressed, X-linked 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CD164 CD164 molecule, sialomucin
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHPT1 choline phosphotransferase 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
EIF5 eukaryotic translation initiation factor 5
FABP7 fatty acid binding protein 7, brain
GNAS GNAS complex locus
HN1 hematological and neurological expressed 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KRT10 keratin 10, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MARCKS myristoylated alanine-rich protein kinase C substrate
MSX1 msh homeobox 1
MXRA7 matrix-remodelling associated 7
PDLIM2 PDZ and LIM domain 2 (mystique)
PEBP1 phosphatidylethanolamine binding protein 1
PKM pyruvate kinase, muscle
PRDX1 peroxiredoxin 1
PRMT1 protein arginine methyltransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
QPRT quinolinate phosphoribosyltransferase
RNASET2 ribonuclease T2
RNF167 ring finger protein 167
S100P S100 calcium binding protein P
SCML1 sex comb on midleg-like 1 (Drosophila)
SLPI secretory leukocyte peptidase inhibitor
STX1A syntaxin 1A (brain)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TUBB tubulin, beta class I