BRD-K67090983_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K67090983_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT9 acyl-CoA thioesterase 9
ADGRE5 adhesion G protein-coupled receptor E5
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
ALDOC aldolase C, fructose-bisphosphate
APOB apolipoprotein B
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
C3AR1 complement component 3a receptor 1
CA11 carbonic anhydrase XI
CALR calreticulin
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CLDN5 claudin 5
COL6A1 collagen, type VI, alpha 1
CORO1A coronin, actin binding protein, 1A
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRABP1 cellular retinoic acid binding protein 1
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
EPAS1 endothelial PAS domain protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EYA1 EYA transcriptional coactivator and phosphatase 1
FADS1 fatty acid desaturase 1
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FERMT2 fermitin family member 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGA fibrinogen alpha chain
FN1 fibronectin 1
FOXO4 forkhead box O4
FSD1 fibronectin type III and SPRY domain containing 1
G0S2 G0/G1 switch 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GBP2 guanylate binding protein 2, interferon-inducible
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
IGSF3 immunoglobulin superfamily, member 3
IL32 interleukin 32
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
KRT23 keratin 23, type I
KRT81 keratin 81, type II
LAMB1 laminin, beta 1
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LHFPL2 lipoma HMGIC fusion partner-like 2
LIMCH1 LIM and calponin homology domains 1
LOXL2 lysyl oxidase-like 2
LRRC17 leucine rich repeat containing 17
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MSMO1 methylsterol monooxygenase 1
MSN moesin
MTMR11 myotubularin related protein 11
NES nestin
NLGN4X neuroligin 4, X-linked
OLFM4 olfactomedin 4
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAM peptidylglycine alpha-amidating monooxygenase
PDE4B phosphodiesterase 4B, cAMP-specific
PEG10 paternally expressed 10
PFKM phosphofructokinase, muscle
PGM1 phosphoglucomutase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PLS1 plastin 1
PNMA2 paraneoplastic Ma antigen 2
PRSS8 protease, serine, 8
PYGL phosphorylase, glycogen, liver
RAB29 RAB29, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP1 retinol binding protein 1, cellular
RIMS3 regulating synaptic membrane exocytosis 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN1 reticulon 1
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SDCBP syndecan binding protein (syntenin)
SELENBP1 selenium binding protein 1
SGCE sarcoglycan, epsilon
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
STMN2 stathmin 2
SYT1 synaptotagmin I
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TSKU tsukushi, small leucine rich proteoglycan
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
FAM57A family with sequence similarity 57, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
ICAM3 intercellular adhesion molecule 3
IFRD2 interferon-related developmental regulator 2
KCTD12 potassium channel tetramerization domain containing 12
LIG1 ligase I, DNA, ATP-dependent
LTF lactotransferrin
MAGEA4 melanoma antigen family A4
MAP7 microtubule-associated protein 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
POSTN periostin, osteoblast specific factor
PPIF peptidylprolyl isomerase F
PURA purine-rich element binding protein A
RFC2 replication factor C (activator 1) 2, 40kDa
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAC3D1 SAC3 domain containing 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
THBS1 thrombospondin 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TSPYL5 TSPY-like 5