BRD-K65955264_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K65955264_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
C2CD2 C2 calcium-dependent domain containing 2
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELF2 CUGBP, Elav-like family member 2
CHIC2 cysteine-rich hydrophobic domain 2
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLC1 DLC1 Rho GTPase activating protein
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EGR1 early growth response 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FGFR4 fibroblast growth factor receptor 4
FILIP1L filamin A interacting protein 1-like
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GYPC glycophorin C (Gerbich blood group)
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LAMP5 lysosomal-associated membrane protein family, member 5
LPL lipoprotein lipase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
RGS1 regulator of G-protein signaling 1
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SPARCL1 SPARC-like 1 (hevin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STK10 serine/threonine kinase 10
SYT1 synaptotagmin I
TFPI2 tissue factor pathway inhibitor 2
UPP1 uridine phosphorylase 1
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
CALML4 calmodulin-like 4
CDC14B cell division cycle 14B
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL12 chemokine (C-X-C motif) ligand 12
DLK1 delta-like 1 homolog (Drosophila)
DMXL2 Dmx-like 2
FBXO9 F-box protein 9
GCA grancalcin, EF-hand calcium binding protein
GRIA2 glutamate receptor, ionotropic, AMPA 2
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIAA0907 KIAA0907
KIF20A kinesin family member 20A
KIF5C kinesin family member 5C
KLK11 kallikrein-related peptidase 11
KYNU kynureninase
LINC00342 long intergenic non-protein coding RNA 342
LTF lactotransferrin
LUC7L3 LUC7-like 3 (S. cerevisiae)
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MRFAP1L1 Morf4 family associated protein 1-like 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PDZK1 PDZ domain containing 1
RSRP1 arginine/serine-rich protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMCO4 single-pass membrane protein with coiled-coil domains 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TSPYL4 TSPY-like 4
TUBB2A tubulin, beta 2A class IIa
VAT1 vesicle amine transport 1
WSB2 WD repeat and SOCS box containing 2