BRD-K65814004_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K65814004_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL2A1 BCL2-related protein A1
C8ORF4 chromosome 8 open reading frame 4
CD24 CD24 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CRISP3 cysteine-rich secretory protein 3
CTSB cathepsin B
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DNMBP dynamin binding protein
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELF1 E74-like factor 1 (ets domain transcription factor)
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPHA2 EPH receptor A2
ERAP2 endoplasmic reticulum aminopeptidase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM60A family with sequence similarity 60, member A
FBXO11 F-box protein 11
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GRB10 growth factor receptor-bound protein 10
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
IER2 immediate early response 2
IER3 immediate early response 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INPP1 inositol polyphosphate-1-phosphatase
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MED13L mediator complex subunit 13-like
NAMPT nicotinamide phosphoribosyltransferase
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PDZK1IP1 PDZK1 interacting protein 1
PF4 platelet factor 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PTX3 pentraxin 3, long
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RND3 Rho family GTPase 3
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SPATS2L spermatogenesis associated, serine-rich 2-like
STK17A serine/threonine kinase 17a
TCL1A T-cell leukemia/lymphoma 1A
TEX10 testis expressed 10
TFF3 trefoil factor 3 (intestinal)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
WEE1 WEE1 G2 checkpoint kinase
ZBTB10 zinc finger and BTB domain containing 10
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASS1 argininosuccinate synthase 1
C6ORF62 chromosome 6 open reading frame 62
CD99 CD99 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CHI3L2 chitinase 3-like 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COLEC12 collectin sub-family member 12
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
EMP2 epithelial membrane protein 2
FCGBP Fc fragment of IgG binding protein
GAS1 growth arrest-specific 1
GJA1 gap junction protein, alpha 1, 43kDa
GOLGA8H golgin A8 family, member H
GPRC5B G protein-coupled receptor, class C, group 5, member B
HMGN3 high mobility group nucleosomal binding domain 3
HSPA8 heat shock 70kDa protein 8
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFRD2 interferon-related developmental regulator 2
IL1R1 interleukin 1 receptor, type I
ITM2A integral membrane protein 2A
KCTD12 potassium channel tetramerization domain containing 12
LPCAT1 lysophosphatidylcholine acyltransferase 1
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MCAM melanoma cell adhesion molecule
METTL3 methyltransferase like 3
MXRA5 matrix-remodelling associated 5
NID2 nidogen 2 (osteonidogen)
NTS neurotensin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG3 paternally expressed 3
PMP22 peripheral myelin protein 22
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
PTGIS prostaglandin I2 (prostacyclin) synthase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPA2 replication protein A2, 32kDa
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPW1 selenoprotein W, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
TBC1D31 TBC1 domain family, member 31
TES testin LIM domain protein
THBS2 thrombospondin 2
TRIP13 thyroid hormone receptor interactor 13
TRPS1 trichorhinophalangeal syndrome I
TXLNA taxilin alpha
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WFDC2 WAP four-disulfide core domain 2
WNT5A wingless-type MMTV integration site family, member 5A
ZFPM2 zinc finger protein, FOG family member 2
ZIC1 Zic family member 1