BRD-K65242613_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-K65242613_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AIM2 absent in melanoma 2
AKAP12 A kinase (PRKA) anchor protein 12
ANXA3 annexin A3
AREG amphiregulin
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C5AR1 complement component 5a receptor 1
CAPN2 calpain 2, (m/II) large subunit
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV2 caveolin 2
CD9 CD9 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHIC2 cysteine-rich hydrophobic domain 2
DDR1 discoidin domain receptor tyrosine kinase 1
DNTT DNA nucleotidylexotransferase
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EREG epiregulin
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
HBEGF heparin-binding EGF-like growth factor
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFNAR1 interferon (alpha, beta and omega) receptor 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KLK5 kallikrein-related peptidase 5
KRT6B keratin 6B, type II
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MYO15B myosin XVB
NAMPT nicotinamide phosphoribosyltransferase
NR4A1 nuclear receptor subfamily 4, group A, member 1
PALLD palladin, cytoskeletal associated protein
PRR7 proline rich 7 (synaptic)
PTX3 pentraxin 3, long
PYGB phosphorylase, glycogen; brain
RHOB ras homolog family member B
RHOC ras homolog family member C
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC22A18 solute carrier family 22, member 18
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
STX3 syntaxin 3
THBS1 thrombospondin 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TRIB1 tribbles pseudokinase 1
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
WT1 Wilms tumor 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AHR aryl hydrocarbon receptor
AMIGO2 adhesion molecule with Ig-like domain 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BRCA1 breast cancer 1, early onset
CCL19 chemokine (C-C motif) ligand 19
CDC20 cell division cycle 20
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CIAPIN1 cytokine induced apoptosis inhibitor 1
CLU clusterin
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
FRZB frizzled-related protein
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GSTM3 glutathione S-transferase mu 3 (brain)
HACD2 3-hydroxyacyl-CoA dehydratase 2
HOXC10 homeobox C10
HOXC6 homeobox C6
IFI44L interferon-induced protein 44-like
IGFBP7 insulin-like growth factor binding protein 7
ITM2A integral membrane protein 2A
LAMP5 lysosomal-associated membrane protein family, member 5
LEPR leptin receptor
LMO2 LIM domain only 2 (rhombotin-like 1)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
MDFIC MyoD family inhibitor domain containing
MMP9 matrix metallopeptidase 9
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
NID2 nidogen 2 (osteonidogen)
NRIP1 nuclear receptor interacting protein 1
PEBP1 phosphatidylethanolamine binding protein 1
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLXNC1 plexin C1
PPIH peptidylprolyl isomerase H (cyclophilin H)
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTTG1 pituitary tumor-transforming 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SFPQ splicing factor proline/glutamine-rich
SPINK1 serine peptidase inhibitor, Kazal type 1
STOM stomatin
TBC1D4 TBC1 domain family, member 4
TMEM97 transmembrane protein 97
TRAM1 translocation associated membrane protein 1
TSPYL5 TSPY-like 5
ZNF318 zinc finger protein 318