BRD-K65182930_NVP-AUY922_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K65182930_NVP-AUY922_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADIRF adipogenesis regulatory factor
AFF1 AF4/FMR2 family, member 1
AGR2 anterior gradient 2
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
BAG3 BCL2-associated athanogene 3
BBX bobby sox homolog (Drosophila)
BDH2 3-hydroxybutyrate dehydrogenase, type 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COBL cordon-bleu WH2 repeat protein
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CPEB1 cytoplasmic polyadenylation element binding protein 1
CRYZ crystallin, zeta (quinone reductase)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DEFB1 defensin, beta 1
DYNLT3 dynein, light chain, Tctex-type 3
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4A2 eukaryotic translation initiation factor 4A2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM134B family with sequence similarity 134, member B
FAM171A1 family with sequence similarity 171, member A1
FAS Fas cell surface death receptor
FXR1 fragile X mental retardation, autosomal homolog 1
GDF15 growth differentiation factor 15
GOLGB1 golgin B1
GPATCH8 G patch domain containing 8
GSTA1 glutathione S-transferase alpha 1
HLA-C major histocompatibility complex, class I, C
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP5 insulin-like growth factor binding protein 5
JAM3 junctional adhesion molecule 3
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA1324 KIAA1324
LAMP1 lysosomal-associated membrane protein 1
LPAR1 lysophosphatidic acid receptor 1
MAP2K6 mitogen-activated protein kinase kinase 6
MAP7 microtubule-associated protein 7
METTL7A methyltransferase like 7A
MFAP3L microfibrillar-associated protein 3-like
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
MT1F metallothionein 1F
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NBR1 neighbor of BRCA1 gene 1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFE2L1 nuclear factor, erythroid 2-like 1
NUCB2 nucleobindin 2
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
PEX11A peroxisomal biogenesis factor 11 alpha
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RHOBTB3 Rho-related BTB domain containing 3
SCGB2A1 secretoglobin, family 2A, member 1
SFRP1 secreted frizzled-related protein 1
STC2 stanniocalcin 2
STK26 serine/threonine protein kinase 26
TMEM47 transmembrane protein 47
TOB1 transducer of ERBB2, 1
TOMM34 translocase of outer mitochondrial membrane 34
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TSPAN7 tetraspanin 7
TSPYL5 TSPY-like 5
UBB ubiquitin B
UGCG UDP-glucose ceramide glucosyltransferase
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
XBP1 X-box binding protein 1
ZBTB20 zinc finger and BTB domain containing 20
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZMAT3 zinc finger, matrin-type 3
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
AMDHD2 amidohydrolase domain containing 2
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CDC45 cell division cycle 45
CKLF chemokine-like factor
CLEC2B C-type lectin domain family 2, member B
CORO1A coronin, actin binding protein, 1A
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
EML3 echinoderm microtubule associated protein like 3
EMP1 epithelial membrane protein 1
FABP4 fatty acid binding protein 4, adipocyte
FEN1 flap structure-specific endonuclease 1
FKBP11 FK506 binding protein 11, 19 kDa
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
INHBA inhibin, beta A
JAG1 jagged 1
LAPTM5 lysosomal protein transmembrane 5
LST1 leukocyte specific transcript 1
MMD monocyte to macrophage differentiation-associated
MMP7 matrix metallopeptidase 7
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
NREP neuronal regeneration related protein
PLN phospholamban
PNP purine nucleoside phosphorylase
POSTN periostin, osteoblast specific factor
PRKCD protein kinase C, delta
PRSS2 protease, serine, 2 (trypsin 2)
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RAD51C RAD51 paralog C
S100A9 S100 calcium binding protein A9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SNAI2 snail family zinc finger 2
SRM spermidine synthase
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SULF1 sulfatase 1
SYNGR3 synaptogyrin 3
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TUBA4A tubulin, alpha 4a
TWF2 twinfilin actin binding protein 2