BRD-K65182930_NVP-AUY922_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K65182930_NVP-AUY922_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BRD4 bromodomain containing 4
CBS cystathionine-beta-synthase
CDH3 cadherin 3, type 1, P-cadherin (placental)
CFB complement factor B
CRYAB crystallin, alpha B
DAPK1 death-associated protein kinase 1
DHCR24 24-dehydrocholesterol reductase
DLG5 discs, large homolog 5 (Drosophila)
DOK5 docking protein 5
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GPC3 glypican 3
GPR143 G protein-coupled receptor 143
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
ITM2C integral membrane protein 2C
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0125 KIAA0125
LITAF lipopolysaccharide-induced TNF factor
MAGED1 melanoma antigen family D1
MAP1A microtubule-associated protein 1A
MSMO1 methylsterol monooxygenase 1
MYH10 myosin, heavy chain 10, non-muscle
MYLK myosin light chain kinase
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIEZO2 piezo-type mechanosensitive ion channel component 2
RGS2 regulator of G-protein signaling 2
RPL31 ribosomal protein L31
SDC2 syndecan 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SQLE squalene epoxidase
SST somatostatin

decreased expression

Symbol Name
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ANXA3 annexin A3
AXL AXL receptor tyrosine kinase
CCND1 cyclin D1
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDCP1 CUB domain containing protein 1
COTL1 coactosin-like F-actin binding protein 1
CYR61 cysteine-rich, angiogenic inducer, 61
DNMBP dynamin binding protein
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFHD2 EF-hand domain family, member D2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HBEGF heparin-binding EGF-like growth factor
HPCAL1 hippocalcin-like 1
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
LGALS3 lectin, galactoside-binding, soluble, 3
MALL mal, T-cell differentiation protein-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM3 minichromosome maintenance complex component 3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PLAU plasminogen activator, urokinase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRF1 perforin 1 (pore forming protein)
RAD23B RAD23 homolog B (S. cerevisiae)
RHOBTB3 Rho-related BTB domain containing 3
RRM2 ribonucleotide reductase M2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SRPX sushi-repeat containing protein, X-linked
TGFA transforming growth factor, alpha
TSPAN7 tetraspanin 7