BRD-K65182930_NVP-AUY922_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

276 genes differentially expressed following the BRD-K65182930_NVP-AUY922_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADI1 acireductone dioxygenase 1
AFF1 AF4/FMR2 family, member 1
AKAP9 A kinase (PRKA) anchor protein 9
AMACR alpha-methylacyl-CoA racemase
ARG2 arginase 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP9A ATPase, class II, type 9A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BBX bobby sox homolog (Drosophila)
BCL2 B-cell CLL/lymphoma 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD8 bromodomain containing 8
BTG1 B-cell translocation gene 1, anti-proliferative
BTN3A2 butyrophilin, subfamily 3, member A2
C1QB complement component 1, q subcomponent, B chain
C8ORF4 chromosome 8 open reading frame 4
CALCOCO2 calcium binding and coiled-coil domain 2
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCDC28A coiled-coil domain containing 28A
CCL20 chemokine (C-C motif) ligand 20
CCNG1 cyclin G1
CCNG2 cyclin G2
CD163 CD163 molecule
CD46 CD46 molecule, complement regulatory protein
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK19 cyclin-dependent kinase 19
CFI complement factor I
CLEC2B C-type lectin domain family 2, member B
COBL cordon-bleu WH2 repeat protein
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
CP ceruloplasmin (ferroxidase)
CREB3L2 cAMP responsive element binding protein 3-like 2
CRYZ crystallin, zeta (quinone reductase)
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DAZAP2 DAZ associated protein 2
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EFCAB14 EF-hand calcium binding domain 14
EGF epidermal growth factor
ENO2 enolase 2 (gamma, neuronal)
EPCAM epithelial cell adhesion molecule
FAM13A family with sequence similarity 13, member A
FOLR1 folate receptor 1 (adult)
FOXJ3 forkhead box J3
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GOLGB1 golgin B1
GOLPH3L golgi phosphoprotein 3-like
GPNMB glycoprotein (transmembrane) nmb
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HCAR3 hydroxycarboxylic acid receptor 3
HECA headcase homolog (Drosophila)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGN3 high mobility group nucleosomal binding domain 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IL1R2 interleukin 1 receptor, type II
INSR insulin receptor
KDM3A lysine (K)-specific demethylase 3A
KIF14 kinesin family member 14
KLHDC10 kelch domain containing 10
KLHL24 kelch-like family member 24
LCN2 lipocalin 2
LDHB lactate dehydrogenase B
LOC100272216 uncharacterized LOC100272216
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LZTFL1 leucine zipper transcription factor-like 1
MAOA monoamine oxidase A
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MBOAT7 membrane bound O-acyltransferase domain containing 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MKRN1 makorin ring finger protein 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
NDRG1 N-myc downstream regulated 1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NPTX2 neuronal pentraxin II
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUCB2 nucleobindin 2
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PERP PERP, TP53 apoptosis effector
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIR pirin (iron-binding nuclear protein)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNRC1 proline-rich nuclear receptor coactivator 1
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS27L ribosomal protein S27-like
RTN3 reticulon 3
SARAF store-operated calcium entry-associated regulatory factor
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SDCBP syndecan binding protein (syntenin)
SECISBP2L SECIS binding protein 2-like
SERINC1 serine incorporator 1
SERINC3 serine incorporator 3
SERINC5 serine incorporator 5
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THSD7A thrombospondin, type I, domain containing 7A
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TXNIP thioredoxin interacting protein
UBXN7 UBX domain protein 7
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VGLL4 vestigial-like family member 4
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
ZBTB38 zinc finger and BTB domain containing 38
ZMAT3 zinc finger, matrin-type 3
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADCY3 adenylate cyclase 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AMDHD2 amidohydrolase domain containing 2
ANPEP alanyl (membrane) aminopeptidase
ASNS asparagine synthetase (glutamine-hydrolyzing)
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
BYSL bystin-like
C1ORF116 chromosome 1 open reading frame 116
C20ORF27 chromosome 20 open reading frame 27
CA2 carbonic anhydrase II
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
COTL1 coactosin-like F-actin binding protein 1
CSTA cystatin A (stefin A)
CTPS1 CTP synthase 1
CXCL14 chemokine (C-X-C motif) ligand 14
DCTPP1 dCTP pyrophosphatase 1
DESI1 desumoylating isopeptidase 1
DLC1 DLC1 Rho GTPase activating protein
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP5 dual specificity phosphatase 5
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FXYD6 FXYD domain containing ion transport regulator 6
GALE UDP-galactose-4-epimerase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HOMER2 homer scaffolding protein 2
HOPX HOP homeobox
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IPO4 importin 4
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL9 kelch-like family member 9
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LAGE3 L antigen family, member 3
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSP1 lymphocyte-specific protein 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MRPL15 mitochondrial ribosomal protein L15
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MX1 MX dynamin-like GTPase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOLC1 nucleolar and coiled-body phosphoprotein 1
NRGN neurogranin (protein kinase C substrate, RC3)
NXT1 nuclear transport factor 2-like export factor 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKM pyruvate kinase, muscle
PNP purine nucleoside phosphorylase
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PPAT phosphoribosyl pyrophosphate amidotransferase
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PUS7 pseudouridylate synthase 7 (putative)
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFTN1 raftlin, lipid raft linker 1
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLBP stem-loop binding protein
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMAD3 SMAD family member 3
SNAP25 synaptosomal-associated protein, 25kDa
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SRM spermidine synthase
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPIN TIMELESS interacting protein
TMEM109 transmembrane protein 109
TNC tenascin C
TOR3A torsin family 3, member A
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
UCK2 uridine-cytidine kinase 2