BRD-K65182930_NVP-AUY922_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

201 genes differentially expressed following the BRD-K65182930_NVP-AUY922_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACTA1 actin, alpha 1, skeletal muscle
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANGPT1 angiopoietin 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C1ORF115 chromosome 1 open reading frame 115
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CDK19 cyclin-dependent kinase 19
CES1 carboxylesterase 1
CHRDL1 chordin-like 1
CKM creatine kinase, muscle
CKS2 CDC28 protein kinase regulatory subunit 2
CLEC3B C-type lectin domain family 3, member B
COL4A5 collagen, type IV, alpha 5
CRABP1 cellular retinoic acid binding protein 1
CRELD2 cysteine-rich with EGF-like domains 2
CRYAB crystallin, alpha B
DAPK1 death-associated protein kinase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEPTOR DEP domain containing MTOR-interacting protein
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF4B eukaryotic translation initiation factor 4B
ELF1 E74-like factor 1 (ets domain transcription factor)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERMP1 endoplasmic reticulum metallopeptidase 1
ERP44 endoplasmic reticulum protein 44
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GOLGB1 golgin B1
GOLM1 golgi membrane protein 1
GPC3 glypican 3
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-E major histocompatibility complex, class I, E
HMBOX1 homeobox containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
JAM2 junctional adhesion molecule 2
KLHL24 kelch-like family member 24
LETMD1 LETM1 domain containing 1
LRRC16A leucine rich repeat containing 16A
LTBP1 latent transforming growth factor beta binding protein 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NEB nebulin
NFE2L1 nuclear factor, erythroid 2-like 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDIA3 protein disulfide isomerase family A, member 3
PEG3 paternally expressed 3
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PROM1 prominin 1
QPRT quinolinate phosphoribosyltransferase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SLN sarcolipin
STK26 serine/threonine protein kinase 26
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBX3 T-box 3
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TNNC1 troponin C type 1 (slow)
TRPS1 trichorhinophalangeal syndrome I
TSPAN13 tetraspanin 13
TTN titin
UBFD1 ubiquitin family domain containing 1
VWF von Willebrand factor
XBP1 X-box binding protein 1
ZC3H11A zinc finger CCCH-type containing 11A
ZNF589 zinc finger protein 589
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
ANXA2 annexin A2
AQP3 aquaporin 3 (Gill blood group)
ARL4C ADP-ribosylation factor-like 4C
ASF1B anti-silencing function 1B histone chaperone
BHLHE40 basic helix-loop-helix family, member e40
BRCA1 breast cancer 1, early onset
CCDC109B coiled-coil domain containing 109B
CCL2 chemokine (C-C motif) ligand 2
CD9 CD9 molecule
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDT1 chromatin licensing and DNA replication factor 1
CENPU centromere protein U
CKLF chemokine-like factor
DEGS1 delta(4)-desaturase, sphingolipid 1
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EAPP E2F-associated phosphoprotein
EFHD2 EF-hand domain family, member D2
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GDF15 growth differentiation factor 15
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GREM1 gremlin 1, DAN family BMP antagonist
HBB hemoglobin, beta
HMBS hydroxymethylbilane synthase
HNMT histamine N-methyltransferase
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
ITGA6 integrin, alpha 6
KCTD12 potassium channel tetramerization domain containing 12
LGALS1 lectin, galactoside-binding, soluble, 1
LIF leukemia inhibitory factor
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MMP7 matrix metallopeptidase 7
MSH2 mutS homolog 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NUP85 nucleoporin 85kDa
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
PCNA proliferating cell nuclear antigen
PCSK1 proprotein convertase subtilisin/kexin type 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSPH phosphoserine phosphatase
PXDN peroxidasin
REG1B regenerating islet-derived 1 beta
RFC4 replication factor C (activator 1) 4, 37kDa
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM2 ribonucleotide reductase M2
S100A6 S100 calcium binding protein A6
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SPON1 spondin 1, extracellular matrix protein
SPRY2 sprouty homolog 2 (Drosophila)
SYNJ2 synaptojanin 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFPI2 tissue factor pathway inhibitor 2
TK1 thymidine kinase 1, soluble
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TUBA4A tubulin, alpha 4a
TYMS thymidylate synthetase
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
USP1 ubiquitin specific peptidase 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VRK1 vaccinia related kinase 1
WSB2 WD repeat and SOCS box containing 2
ZWINT ZW10 interacting kinetochore protein