BRD-K65182930_NVP-AUY922_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

223 genes differentially expressed following the BRD-K65182930_NVP-AUY922_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACBD3 acyl-CoA binding domain containing 3
ADCY9 adenylate cyclase 9
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AKAP9 A kinase (PRKA) anchor protein 9
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AQP1 aquaporin 1 (Colton blood group)
ASS1 argininosuccinate synthase 1
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX1 brain expressed, X-linked 1
C6ORF48 chromosome 6 open reading frame 48
CALCA calcitonin-related polypeptide alpha
CAMLG calcium modulating ligand
CAT catalase
CCNG1 cyclin G1
CES1 carboxylesterase 1
CGA glycoprotein hormones, alpha polypeptide
CHGB chromogranin B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC3B C-type lectin domain family 3, member B
COBL cordon-bleu WH2 repeat protein
CRYAB crystallin, alpha B
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DENND2D DENN/MADD domain containing 2D
DIAPH2 diaphanous-related formin 2
DPP4 dipeptidyl-peptidase 4
DSP desmoplakin
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ECHDC2 enoyl CoA hydratase domain containing 2
EGFR epidermal growth factor receptor
EIF4B eukaryotic translation initiation factor 4B
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPCAM epithelial cell adhesion molecule
FAM134B family with sequence similarity 134, member B
FAM46A family with sequence similarity 46, member A
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
FZD7 frizzled class receptor 7
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS6 growth arrest-specific 6
GLUL glutamate-ammonia ligase
GOLPH3L golgi phosphoprotein 3-like
GPX3 glutathione peroxidase 3
GSTA1 glutathione S-transferase alpha 1
HECA headcase homolog (Drosophila)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
INSM1 insulinoma-associated 1
IRS2 insulin receptor substrate 2
IRX5 iroquois homeobox 5
KLHL24 kelch-like family member 24
KRT13 keratin 13, type I
KRT5 keratin 5, type II
LPL lipoprotein lipase
LRRC16A leucine rich repeat containing 16A
LXN latexin
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MATN2 matrilin 2
MERTK MER proto-oncogene, tyrosine kinase
MFAP5 microfibrillar associated protein 5
MKRN1 makorin ring finger protein 1
MSMB microseminoprotein, beta-
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NR1H2 nuclear receptor subfamily 1, group H, member 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1 PDZ domain containing 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PTTG1 pituitary tumor-transforming 1
QDPR quinoid dihydropteridine reductase
RAB9A RAB9A, member RAS oncogene family
RBKS ribokinase
RORA RAR-related orphan receptor A
RPL28 ribosomal protein L28
RPL31 ribosomal protein L31
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK26 serine/threonine protein kinase 26
THSD7A thrombospondin, type I, domain containing 7A
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TTC39A tetratricopeptide repeat domain 39A
TUSC3 tumor suppressor candidate 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WISP2 WNT1 inducible signaling pathway protein 2

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AKAP12 A kinase (PRKA) anchor protein 12
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
ASPH aspartate beta-hydroxylase
ASRGL1 asparaginase like 1
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
CCDC85B coiled-coil domain containing 85B
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CD47 CD47 molecule
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK2 cyclin-dependent kinase 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPU centromere protein U
CKLF chemokine-like factor
COL5A2 collagen, type V, alpha 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPYD dihydropyrimidine dehydrogenase
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
ETV1 ets variant 1
ETV5 ets variant 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOSL1 FOS-like antigen 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GPM6A glycoprotein M6A
H2AFX H2A histone family, member X
HNMT histamine N-methyltransferase
HOPX HOP homeobox
HOXB7 homeobox B7
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGB1BP1 integrin beta 1 binding protein 1
KYNU kynureninase
LHX2 LIM homeobox 2
LOC100505650 uncharacterized LOC100505650
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPK1 mitogen-activated protein kinase 1
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
MEF2C myocyte enhancer factor 2C
MET MET proto-oncogene, receptor tyrosine kinase
METRN meteorin, glial cell differentiation regulator
MMD monocyte to macrophage differentiation-associated
MMP7 matrix metallopeptidase 7
MT2A metallothionein 2A
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NAV3 neuron navigator 3
NRGN neurogranin (protein kinase C substrate, RC3)
NRP1 neuropilin 1
NT5DC2 5'-nucleotidase domain containing 2
NT5E 5'-nucleotidase, ecto (CD73)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PHTF2 putative homeodomain transcription factor 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRD protein tyrosine phosphatase, receptor type, D
RANBP1 RAN binding protein 1
RFTN1 raftlin, lipid raft linker 1
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SMAD1 SMAD family member 1
SOBP sine oculis binding protein homolog (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY4 sprouty homolog 4 (Drosophila)
SRPX2 sushi-repeat containing protein, X-linked 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TACC1 transforming, acidic coiled-coil containing protein 1
TAGLN2 transgelin 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
THBS2 thrombospondin 2
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TRAPPC4 trafficking protein particle complex 4
TRIB3 tribbles pseudokinase 3
TUBG1 tubulin, gamma 1
TYRP1 tyrosinase-related protein 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
WNT5A wingless-type MMTV integration site family, member 5A
WSB2 WD repeat and SOCS box containing 2
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta