BRD-K64890080_BI-2536_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

189 genes differentially expressed following the BRD-K64890080_BI-2536_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ADM adrenomedullin
ALB albumin
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
BTG1 B-cell translocation gene 1, anti-proliferative
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CD9 CD9 molecule
CDC42 cell division cycle 42
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CIRBP cold inducible RNA binding protein
CLC Charcot-Leyden crystal galectin
CLIC5 chloride intracellular channel 5
CNOT4 CCR4-NOT transcription complex, subunit 4
CORO1A coronin, actin binding protein, 1A
CORO1C coronin, actin binding protein, 1C
DCAF10 DDB1 and CUL4 associated factor 10
DEFA4 defensin, alpha 4, corticostatin
DENND1B DENN/MADD domain containing 1B
DMBT1 deleted in malignant brain tumors 1
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP5 dual specificity phosphatase 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EZR ezrin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBP1 fructose-1,6-bisphosphatase 1
FN1 fibronectin 1
FUCA1 fucosidase, alpha-L- 1, tissue
GFOD1 glucose-fructose oxidoreductase domain containing 1
GJA1 gap junction protein, alpha 1, 43kDa
GLS glutaminase
GM2A GM2 ganglioside activator
GPRC5A G protein-coupled receptor, class C, group 5, member A
H2BFS H2B histone family, member S (pseudogene)
HAPLN1 hyaluronan and proteoglycan link protein 1
HEBP1 heme binding protein 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMMR hyaluronan-mediated motility receptor (RHAMM)
IER5 immediate early response 5
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL13RA2 interleukin 13 receptor, alpha 2
ITGB4 integrin, beta 4
KIF2C kinesin family member 2C
LAMP1 lysosomal-associated membrane protein 1
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
LTF lactotransferrin
LYZ lysozyme
MT1F metallothionein 1F
MT1G metallothionein 1G
MTSS1 metastasis suppressor 1
NCAM1 neural cell adhesion molecule 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCDH9 protocadherin 9
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PSD3 pleckstrin and Sec7 domain containing 3
QPCT glutaminyl-peptide cyclotransferase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS13 regulator of G-protein signaling 13
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SYT1 synaptotagmin I
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TMEM2 transmembrane protein 2
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TUBB6 tubulin, beta 6 class V
TXNIP thioredoxin interacting protein
XIST X inactive specific transcript (non-protein coding)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AK2 adenylate kinase 2
ASPN asporin
ATF1 activating transcription factor 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE41 basic helix-loop-helix family, member e41
BST2 bone marrow stromal cell antigen 2
C1S complement component 1, s subcomponent
C3 complement component 3
CA12 carbonic anhydrase XII
CCL2 chemokine (C-C motif) ligand 2
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CDK4 cyclin-dependent kinase 4
COL15A1 collagen, type XV, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL1A1 collagen, type I, alpha 1
COMT catechol-O-methyltransferase
CPE carboxypeptidase E
CX3CR1 chemokine (C-X3-C motif) receptor 1
EFS embryonal Fyn-associated substrate
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAP fibroblast activation protein, alpha
FBLN1 fibulin 1
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FKBP10 FK506 binding protein 10, 65 kDa
FLT3 fms-related tyrosine kinase 3
FMOD fibromodulin
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GAS1 growth arrest-specific 1
GBP2 guanylate binding protein 2, interferon-inducible
GGCT gamma-glutamylcyclotransferase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HACD3 3-hydroxyacyl-CoA dehydratase 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXB7 homeobox B7
HSPB8 heat shock 22kDa protein 8
IFRD2 interferon-related developmental regulator 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGLV3-19 immunoglobulin lambda variable 3-19
INHBB inhibin, beta B
ITGA7 integrin, alpha 7
ITM2A integral membrane protein 2A
KRT17 keratin 17, type I
KRT18 keratin 18, type I
LOX lysyl oxidase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MBP myelin basic protein
MRPL3 mitochondrial ribosomal protein L3
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MTA1 metastasis associated 1
MXRA5 matrix-remodelling associated 5
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NDRG2 NDRG family member 2
NNMT nicotinamide N-methyltransferase
NT5DC2 5'-nucleotidase domain containing 2
NUPR1 nuclear protein, transcriptional regulator, 1
PARP2 poly (ADP-ribose) polymerase 2
PDGFRL platelet-derived growth factor receptor-like
PDLIM2 PDZ and LIM domain 2 (mystique)
PDZD2 PDZ domain containing 2
PGAP3 post-GPI attachment to proteins 3
PLAC8 placenta-specific 8
POSTN periostin, osteoblast specific factor
PPAP2A phosphatidic acid phosphatase type 2A
PPIF peptidylprolyl isomerase F
PPT1 palmitoyl-protein thioesterase 1
PRDX2 peroxiredoxin 2
PRKCH protein kinase C, eta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCR1 pyrroline-5-carboxylate reductase 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN1 regulator of calcineurin 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS5 regulator of G-protein signaling 5
RNF167 ring finger protein 167
SCGB2A2 secretoglobin, family 2A, member 2
SCP2 sterol carrier protein 2
SEC23B Sec23 homolog B (S. cerevisiae)
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SLC35F2 solute carrier family 35, member F2
SPATS2L spermatogenesis associated, serine-rich 2-like
SPDEF SAM pointed domain containing ETS transcription factor
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TARBP1 TAR (HIV-1) RNA binding protein 1
TGFB3 transforming growth factor, beta 3
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
VCAN versican
XBP1 X-box binding protein 1
ZBTB20 zinc finger and BTB domain containing 20