BRD-K64890080_BI-2536_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

207 genes differentially expressed following the BRD-K64890080_BI-2536_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ARHGAP29 Rho GTPase activating protein 29
BAMBI BMP and activin membrane-bound inhibitor
BRD4 bromodomain containing 4
CADM1 cell adhesion molecule 1
CCDC85B coiled-coil domain containing 85B
CCDC92 coiled-coil domain containing 92
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CELF2 CUGBP, Elav-like family member 2
CLIC5 chloride intracellular channel 5
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
DAPK1 death-associated protein kinase 1
DFNA5 deafness, autosomal dominant 5
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DST dystonin
EDNRB endothelin receptor type B
ENAH enabled homolog (Drosophila)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ETV5 ets variant 5
FAM50A family with sequence similarity 50, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FOLR1 folate receptor 1 (adult)
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD7 frizzled class receptor 7
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB14 growth factor receptor-bound protein 14
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BG histone cluster 1, H2bg
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HSPA2 heat shock 70kDa protein 2
IER5 immediate early response 5
IFI6 interferon, alpha-inducible protein 6
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL13RA2 interleukin 13 receptor, alpha 2
INSR insulin receptor
ITGA6 integrin, alpha 6
JARID2 jumonji, AT rich interactive domain 2
KIF5C kinesin family member 5C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LUC7L3 LUC7-like 3 (S. cerevisiae)
MACF1 microtubule-actin crosslinking factor 1
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MCAM melanoma cell adhesion molecule
MCOLN1 mucolipin 1
MFAP5 microfibrillar associated protein 5
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MTUS1 microtubule associated tumor suppressor 1
MYO1B myosin IB
NCAM1 neural cell adhesion molecule 1
NDNF neuron-derived neurotrophic factor
NMT2 N-myristoyltransferase 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
ODC1 ornithine decarboxylase 1
PCDH17 protocadherin 17
PCDH9 protocadherin 9
PEG10 paternally expressed 10
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PKN2 protein kinase N2
PLK2 polo-like kinase 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RPL31 ribosomal protein L31
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SERINC5 serine incorporator 5
SLC31A2 solute carrier family 31 (copper transporter), member 2
STK3 serine/threonine kinase 3
STXBP1 syntaxin binding protein 1
TEX2 testis expressed 2
TPST2 tyrosylprotein sulfotransferase 2
TUBB2B tubulin, beta 2B class IIb
UBE2S ubiquitin-conjugating enzyme E2S
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFP36 ZFP36 ring finger protein
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADGRG1 adhesion G protein-coupled receptor G1
ADIRF adipogenesis regulatory factor
AIM1 absent in melanoma 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANPEP alanyl (membrane) aminopeptidase
AQP3 aquaporin 3 (Gill blood group)
ATP9A ATPase, class II, type 9A
C1S complement component 1, s subcomponent
C3 complement component 3
CA12 carbonic anhydrase XII
CALML3 calmodulin-like 3
CCNB2 cyclin B2
CCND2 cyclin D2
CD99 CD99 molecule
CFD complement factor D (adipsin)
CLEC2B C-type lectin domain family 2, member B
COCH cochlin
COL1A2 collagen, type I, alpha 2
COL4A2 collagen, type IV, alpha 2
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
DENND2D DENN/MADD domain containing 2D
DHRS3 dehydrogenase/reductase (SDR family) member 3
EAPP E2F-associated phosphoprotein
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL6 ELOVL fatty acid elongase 6
FAM129A family with sequence similarity 129, member A
FCGBP Fc fragment of IgG binding protein
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOXF2 forkhead box F2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
HMGA2 high mobility group AT-hook 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOXB7 homeobox B7
HSPB1 heat shock 27kDa protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL1B interleukin 1, beta
IL7R interleukin 7 receptor
ITM2A integral membrane protein 2A
JADE2 jade family PHD finger 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIAA0101 KIAA0101
KRT15 keratin 15, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT8 keratin 8, type II
KYNU kynureninase
LGALS2 lectin, galactoside-binding, soluble, 2
LIPA lipase A, lysosomal acid, cholesterol esterase
LOX lysyl oxidase
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LTBP1 latent transforming growth factor beta binding protein 1
MAPK13 mitogen-activated protein kinase 13
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MFAP4 microfibrillar-associated protein 4
MGST2 microsomal glutathione S-transferase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOCOS molybdenum cofactor sulfurase
MRPS2 mitochondrial ribosomal protein S2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NMI N-myc (and STAT) interactor
NREP neuronal regeneration related protein
OLFM4 olfactomedin 4
PDZK1IP1 PDZK1 interacting protein 1
PLAC8 placenta-specific 8
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB25 RAB25, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
S100A7 S100 calcium binding protein A7
SDC1 syndecan 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLURP1 secreted LY6/PLAUR domain containing 1
SORBS3 sorbin and SH3 domain containing 3
SOX11 SRY (sex determining region Y)-box 11
SPDEF SAM pointed domain containing ETS transcription factor
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPRR1A small proline-rich protein 1A
ST14 suppression of tumorigenicity 14 (colon carcinoma)
TACSTD2 tumor-associated calcium signal transducer 2
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM97 transmembrane protein 97
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TP63 tumor protein p63
TPBG trophoblast glycoprotein
TRIM16 tripartite motif containing 16
TSC22D1 TSC22 domain family, member 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican
WFDC2 WAP four-disulfide core domain 2
WNT5A wingless-type MMTV integration site family, member 5A