BRD-K64890080_BI-2536_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K64890080_BI-2536_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA4 annexin A4
ASRGL1 asparaginase like 1
BAMBI BMP and activin membrane-bound inhibitor
BLNK B-cell linker
BTG2 BTG family, member 2
C5AR1 complement component 5a receptor 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CLDN10 claudin 10
DEFB1 defensin, beta 1
EGR1 early growth response 1
EGR3 early growth response 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HP haptoglobin
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHD immunoglobulin heavy constant delta
INSIG1 insulin induced gene 1
KLF9 Kruppel-like factor 9
KLK6 kallikrein-related peptidase 6
KRT23 keratin 23, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LGMN legumain
LOC100505650 uncharacterized LOC100505650
LXN latexin
MSX1 msh homeobox 1
MTSS1 metastasis suppressor 1
MUC16 mucin 16, cell surface associated
NNMT nicotinamide N-methyltransferase
NOTCH1 notch 1
NPR3 natriuretic peptide receptor 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
POSTN periostin, osteoblast specific factor
PRR15L proline rich 15-like
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RNASE6 ribonuclease, RNase A family, k6
SCGB2A1 secretoglobin, family 2A, member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLPI secretory leukocyte peptidase inhibitor
SST somatostatin
TFRC transferrin receptor
THBS2 thrombospondin 2
TM7SF2 transmembrane 7 superfamily member 2
TMEM2 transmembrane protein 2
TUBA4A tubulin, alpha 4a
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ANK2 ankyrin 2, neuronal
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BMP4 bone morphogenetic protein 4
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CCL5 chemokine (C-C motif) ligand 5
CD44 CD44 molecule (Indian blood group)
CDCA4 cell division cycle associated 4
CHN1 chimerin 1
CHPT1 choline phosphotransferase 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EGFR epidermal growth factor receptor
FRZB frizzled-related protein
GATA3 GATA binding protein 3
GBP1 guanylate binding protein 1, interferon-inducible
GPR171 G protein-coupled receptor 171
HOPX HOP homeobox
HOXA10 homeobox A10
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MSLN mesothelin
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUP62 nucleoporin 62kDa
OLFM4 olfactomedin 4
PDGFRL platelet-derived growth factor receptor-like
PHLDA1 pleckstrin homology-like domain, family A, member 1
PSRC1 proline/serine-rich coiled-coil 1
RAD51C RAD51 paralog C
RGS5 regulator of G-protein signaling 5
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TARP TCR gamma alternate reading frame protein
TRBC1 T cell receptor beta constant 1
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
VGLL4 vestigial-like family member 4
WEE1 WEE1 G2 checkpoint kinase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB18 zinc finger and BTB domain containing 18
ZHX2 zinc fingers and homeoboxes 2