BRD-K64890080_BI-2536_HS578T_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K64890080_BI-2536_HS578T_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACAA1 acetyl-CoA acyltransferase 1
ACLY ATP citrate lyase
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AQP1 aquaporin 1 (Colton blood group)
ATP2A3 ATPase, Ca++ transporting, ubiquitous
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCNG1 cyclin G1
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLDN10 claudin 10
CLU clusterin
CRIP1 cysteine-rich protein 1 (intestinal)
CYBA cytochrome b-245, alpha polypeptide
DCN decorin
DLK1 delta-like 1 homolog (Drosophila)
DMBT1 deleted in malignant brain tumors 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDN3 endothelin 3
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
INSIG1 insulin induced gene 1
ITM2C integral membrane protein 2C
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM4B lysine (K)-specific demethylase 4B
KIF2C kinesin family member 2C
LTF lactotransferrin
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2A1 mannosidase, alpha, class 2A, member 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG10 paternally expressed 10
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PON3 paraoxonase 3
PROM1 prominin 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RRAD Ras-related associated with diabetes
RSRP1 arginine/serine-rich protein 1
RUNX3 runt-related transcription factor 3
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SPP1 secreted phosphoprotein 1
STK10 serine/threonine kinase 10
TGM2 transglutaminase 2
THAP11 THAP domain containing 11
TRH thyrotropin-releasing hormone
TSPAN12 tetraspanin 12
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
WFDC1 WAP four-disulfide core domain 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ANXA3 annexin A3
APOD apolipoprotein D
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
AUTS2 autism susceptibility candidate 2
C2CD2 C2 calcium-dependent domain containing 2
C2CD5 C2 calcium-dependent domain containing 5
CCL2 chemokine (C-C motif) ligand 2
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DST dystonin
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EREG epiregulin
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
HLA-DRA major histocompatibility complex, class II, DR alpha
HOXA10 homeobox A10
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRS2 insulin receptor substrate 2
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
MARCKS myristoylated alanine-rich protein kinase C substrate
NGRN neugrin, neurite outgrowth associated
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PEX11A peroxisomal biogenesis factor 11 alpha
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POSTN periostin, osteoblast specific factor
RAD23B RAD23 homolog B (S. cerevisiae)
RFC4 replication factor C (activator 1) 4, 37kDa
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SIRT3 sirtuin 3
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPRR1A small proline-rich protein 1A
SYBU syntabulin (syntaxin-interacting)
TLR4 toll-like receptor 4
WT1 Wilms tumor 1