BRD-K64890080_BI-2536_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-K64890080_BI-2536_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKIRIN1 akirin 1
ASCL1 achaete-scute family bHLH transcription factor 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCNF cyclin F
CD9 CD9 molecule
COL11A1 collagen, type XI, alpha 1
DEGS1 delta(4)-desaturase, sphingolipid 1
FHL1 four and a half LIM domains 1
GAS1 growth arrest-specific 1
GMPR guanosine monophosphate reductase
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H1C histone cluster 1, H1c
HMG20B high mobility group 20B
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LGMN legumain
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCALD neurocalcin delta
PALLD palladin, cytoskeletal associated protein
PDLIM3 PDZ and LIM domain 3
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLCB4 phospholipase C, beta 4
RAB31 RAB31, member RAS oncogene family
RGS13 regulator of G-protein signaling 13
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SQSTM1 sequestosome 1
TACC1 transforming, acidic coiled-coil containing protein 1
TMEM2 transmembrane protein 2
TUBB2B tubulin, beta 2B class IIb
TUBB6 tubulin, beta 6 class V
UBE2S ubiquitin-conjugating enzyme E2S
VNN1 vanin 1

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHNAK2 AHNAK nucleoprotein 2
AHR aryl hydrocarbon receptor
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA4 annexin A4
APOC2 apolipoprotein C-II
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C5 complement component 5
CA12 carbonic anhydrase XII
CALB1 calbindin 1, 28kDa
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD93 CD93 molecule
CDK1 cyclin-dependent kinase 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CFD complement factor D (adipsin)
CFI complement factor I
CFLAR CASP8 and FADD-like apoptosis regulator
CIDEB cell death-inducing DFFA-like effector b
CLDN4 claudin 4
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL6 chemokine (C-X-C motif) ligand 6
DEFB1 defensin, beta 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
EVI2A ecotropic viral integration site 2A
FAM60A family with sequence similarity 60, member A
FCGBP Fc fragment of IgG binding protein
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
GPX3 glutathione peroxidase 3
HBB hemoglobin, beta
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HRH1 histamine receptor H1
ICAM3 intercellular adhesion molecule 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KRT18 keratin 18, type I
LOX lysyl oxidase
LPL lipoprotein lipase
LTF lactotransferrin
LYZ lysozyme
MDK midkine (neurite growth-promoting factor 2)
MET MET proto-oncogene, receptor tyrosine kinase
MGP matrix Gla protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP7 matrix metallopeptidase 7
MPZL2 myelin protein zero-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NMI N-myc (and STAT) interactor
NRCAM neuronal cell adhesion molecule
NREP neuronal regeneration related protein
NXT2 nuclear transport factor 2-like export factor 2
PENK proenkephalin
PERP PERP, TP53 apoptosis effector
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSPH phosphoserine phosphatase
PTBP3 polypyrimidine tract binding protein 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE4 ribonuclease, RNase A family, 4
RPL38 ribosomal protein L38
S100P S100 calcium binding protein P
SEPP1 selenoprotein P, plasma, 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SORBS2 sorbin and SH3 domain containing 2
SORBS3 sorbin and SH3 domain containing 3
SOX4 SRY (sex determining region Y)-box 4
SPP1 secreted phosphoprotein 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SYBU syntabulin (syntaxin-interacting)
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN6 tetraspanin 6
UBE2C ubiquitin-conjugating enzyme E2C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VAV3 vav 3 guanine nucleotide exchange factor
XBP1 X-box binding protein 1