BRD-K64890080_BI-2536_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

209 genes differentially expressed following the BRD-K64890080_BI-2536_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRL2 adhesion G protein-coupled receptor L2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALB albumin
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BEX1 brain expressed, X-linked 1
BIK BCL2-interacting killer (apoptosis-inducing)
C11ORF71 chromosome 11 open reading frame 71
C14ORF132 chromosome 14 open reading frame 132
C4BPA complement component 4 binding protein, alpha
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL20 chemokine (C-C motif) ligand 20
CD36 CD36 molecule (thrombospondin receptor)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLDN10 claudin 10
COL13A1 collagen, type XIII, alpha 1
COX17 COX17 cytochrome c oxidase copper chaperone
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CREG1 cellular repressor of E1A-stimulated genes 1
CSTB cystatin B (stefin B)
CTSB cathepsin B
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DSC3 desmocollin 3
DSP desmoplakin
DUSP14 dual specificity phosphatase 14
EFNB2 ephrin-B2
EGR1 early growth response 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
F8 coagulation factor VIII, procoagulant component
FDXR ferredoxin reductase
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD7 frizzled class receptor 7
GAGE3 G antigen 3
GALC galactosylceramidase
GLCE glucuronic acid epimerase
GOLGA8H golgin A8 family, member H
GPM6B glycoprotein M6B
GSTA4 glutathione S-transferase alpha 4
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
ITGA6 integrin, alpha 6
KDM6A lysine (K)-specific demethylase 6A
KIAA1033 KIAA1033
KIF2C kinesin family member 2C
KRT14 keratin 14, type I
LYZ lysozyme
MAP1A microtubule-associated protein 1A
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MT1E metallothionein 1E
MT1H metallothionein 1H
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYO1B myosin IB
MYO6 myosin VI
NCAM1 neural cell adhesion molecule 1
NMU neuromedin U
NPTX2 neuronal pentraxin II
NTS neurotensin
ODC1 ornithine decarboxylase 1
ORM1 orosomucoid 1
PBX3 pre-B-cell leukemia homeobox 3
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFA platelet-derived growth factor alpha polypeptide
PDZD2 PDZ domain containing 2
PEG3 paternally expressed 3
PRAF2 PRA1 domain family, member 2
PRAME preferentially expressed antigen in melanoma
PSAT1 phosphoserine aminotransferase 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SC5D sterol-C5-desaturase
SCAND1 SCAN domain containing 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SESN1 sestrin 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX11 sorting nexin 11
SRGN serglycin
SSFA2 sperm specific antigen 2
STXBP1 syntaxin binding protein 1
TAC1 tachykinin, precursor 1
TDRD7 tudor domain containing 7
TIAM1 T-cell lymphoma invasion and metastasis 1
TKTL1 transketolase-like 1
TLK2 tousled-like kinase 2
TM7SF2 transmembrane 7 superfamily member 2
TMEM14A transmembrane protein 14A
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
WASF3 WAS protein family, member 3
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACSL5 acyl-CoA synthetase long-chain family member 5
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
APOD apolipoprotein D
ATF1 activating transcription factor 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BACE2 beta-site APP-cleaving enzyme 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDK4 cyclin-dependent kinase 4
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CYR61 cysteine-rich, angiogenic inducer, 61
DHRS3 dehydrogenase/reductase (SDR family) member 3
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP3 dual specificity phosphatase 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
F3 coagulation factor III (thromboplastin, tissue factor)
FAM57A family with sequence similarity 57, member A
FBLN1 fibulin 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GBP1 guanylate binding protein 1, interferon-inducible
GPX3 glutathione peroxidase 3
HOPX HOP homeobox
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPB1 heat shock 27kDa protein 1
IFRD2 interferon-related developmental regulator 2
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IRS1 insulin receptor substrate 1
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPAR1 lysophosphatidic acid receptor 1
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LY6E lymphocyte antigen 6 complex, locus E
MAL mal, T-cell differentiation protein
MAPK13 mitogen-activated protein kinase 13
MET MET proto-oncogene, receptor tyrosine kinase
METTL21B methyltransferase like 21B
MSH6 mutS homolog 6
MYOF myoferlin
NFIB nuclear factor I/B
NME4 NME/NM23 nucleoside diphosphate kinase 4
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PIP prolactin-induced protein
PPAP2C phosphatidic acid phosphatase type 2C
PRKCD protein kinase C, delta
PRNP prion protein
PSCA prostate stem cell antigen
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCR1 pyrroline-5-carboxylate reductase 1
RAB25 RAB25, member RAS oncogene family
RAI14 retinoic acid induced 14
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBPMS RNA binding protein with multiple splicing
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGCC regulator of cell cycle
RPL31 ribosomal protein L31
S100P S100 calcium binding protein P
SCRN1 secernin 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BP4 SH3-domain binding protein 4
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SORBS3 sorbin and SH3 domain containing 3
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TFPI2 tissue factor pathway inhibitor 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE2 transducin-like enhancer of split 2
TNS3 tensin 3
TPM1 tropomyosin 1 (alpha)
TRIP6 thyroid hormone receptor interactor 6
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TSPAN31 tetraspanin 31
TSPAN4 tetraspanin 4
VCAN versican
VGLL1 vestigial-like family member 1