BRD-K64800655_PHA-793887_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

179 genes differentially expressed following the BRD-K64800655_PHA-793887_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAM28 ADAM metallopeptidase domain 28
ADIRF adipogenesis regulatory factor
AK4 adenylate kinase 4
AP3D1 adaptor-related protein complex 3, delta 1 subunit
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ASS1 argininosuccinate synthase 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2A1 BCL2-related protein A1
BLNK B-cell linker
C1ORF116 chromosome 1 open reading frame 116
CA11 carbonic anhydrase XI
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCDC85B coiled-coil domain containing 85B
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD52 CD52 molecule
CDC42SE1 CDC42 small effector 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
COL11A1 collagen, type XI, alpha 1
CRNN cornulin
CXCL14 chemokine (C-X-C motif) ligand 14
CYLD cylindromatosis (turban tumor syndrome)
DACH1 dachshund family transcription factor 1
DENND2D DENN/MADD domain containing 2D
DUSP3 dual specificity phosphatase 3
F12 coagulation factor XII (Hageman factor)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GREM1 gremlin 1, DAN family BMP antagonist
GTF2B general transcription factor IIB
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HOPX HOP homeobox
HP haptoglobin
HSBP1 heat shock factor binding protein 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFITM1 interferon induced transmembrane protein 1
IL1RN interleukin 1 receptor antagonist
MDFIC MyoD family inhibitor domain containing
MGLL monoglyceride lipase
MMD monocyte to macrophage differentiation-associated
MXI1 MAX interactor 1, dimerization protein
NEBL nebulette
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCP4 Purkinje cell protein 4
PDZK1IP1 PDZK1 interacting protein 1
PLA1A phospholipase A1 member A
PPIF peptidylprolyl isomerase F
PPIG peptidylprolyl isomerase G (cyclophilin G)
PPL periplakin
PRKCH protein kinase C, eta
PRR7 proline rich 7 (synaptic)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB20 RAB20, member RAS oncogene family
REG1A regenerating islet-derived 1 alpha
RHOF ras homolog family member F (in filopodia)
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RNF113A ring finger protein 113A
RPL31 ribosomal protein L31
RRAGD Ras-related GTP binding D
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
STK26 serine/threonine protein kinase 26
TRAPPC6A trafficking protein particle complex 6A
TRPS1 trichorhinophalangeal syndrome I
TSPAN12 tetraspanin 12
ZMYM2 zinc finger, MYM-type 2
ZNF185 zinc finger protein 185 (LIM domain)
ZNF43 zinc finger protein 43
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
AKAP12 A kinase (PRKA) anchor protein 12
ANPEP alanyl (membrane) aminopeptidase
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AURKB aurora kinase B
BLMH bleomycin hydrolase
C2CD5 C2 calcium-dependent domain containing 5
C6ORF62 chromosome 6 open reading frame 62
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CIRBP cold inducible RNA binding protein
COPS7A COP9 signalosome subunit 7A
CSE1L CSE1 chromosome segregation 1-like (yeast)
DDIT4 DNA-damage-inducible transcript 4
DEK DEK proto-oncogene
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ELOVL2 ELOVL fatty acid elongase 2
FOXM1 forkhead box M1
FYN FYN proto-oncogene, Src family tyrosine kinase
GTPBP8 GTP-binding protein 8 (putative)
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
JCHAIN joining chain of multimeric IgA and IgM
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KLF2 Kruppel-like factor 2
KLHL9 kelch-like family member 9
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LYZ lysozyme
MACF1 microtubule-actin crosslinking factor 1
MARCKSL1 MARCKS-like 1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MTUS1 microtubule associated tumor suppressor 1
MYBPC1 myosin binding protein C, slow type
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEFL neurofilament, light polypeptide
NES nestin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUSAP1 nucleolar and spindle associated protein 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PBX1 pre-B-cell leukemia homeobox 1
PEBP1 phosphatidylethanolamine binding protein 1
PFN2 profilin 2
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PSIP1 PC4 and SFRS1 interacting protein 1
RRM2 ribonucleotide reductase M2
SDC2 syndecan 2
SGK1 serum/glucocorticoid regulated kinase 1
SMC4 structural maintenance of chromosomes 4
SOX4 SRY (sex determining region Y)-box 4
SPC25 SPC25, NDC80 kinetochore complex component
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
STMN1 stathmin 1
TMPO thymopoietin
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPX2 TPX2, microtubule-associated
TRMT5 tRNA methyltransferase 5
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta