BRD-K64800655_PHA-793887_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K64800655_PHA-793887_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADGRF5 adhesion G protein-coupled receptor F5
AREG amphiregulin
ASPN asporin
BAG3 BCL2-associated athanogene 3
BTG3 BTG family, member 3
CCP110 centriolar coiled coil protein 110kDa
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDCP1 CUB domain containing protein 1
COL11A1 collagen, type XI, alpha 1
COL4A1 collagen, type IV, alpha 1
COL5A1 collagen, type V, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CTTN cortactin
DHRS2 dehydrogenase/reductase (SDR family) member 2
EDNRA endothelin receptor type A
EXOSC4 exosome component 4
FBLN1 fibulin 1
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPRC5A G protein-coupled receptor, class C, group 5, member A
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BK histone cluster 1, H2bk
HSPH1 heat shock 105kDa/110kDa protein 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LAMC2 laminin, gamma 2
LIMCH1 LIM and calponin homology domains 1
LTA4H leukotriene A4 hydrolase
MACF1 microtubule-actin crosslinking factor 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP7 matrix metallopeptidase 7
NBL1 neuroblastoma 1, DAN family BMP antagonist
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAWR PRKC, apoptosis, WT1, regulator
PCDH17 protocadherin 17
PIEZO2 piezo-type mechanosensitive ion channel component 2
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPME1 protein phosphatase methylesterase 1
PTRF polymerase I and transcript release factor
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RBM34 RNA binding motif protein 34
RBP1 retinol binding protein 1, cellular
S100A2 S100 calcium binding protein A2
SCG5 secretogranin V
SDC4 syndecan 4
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORD sorbitol dehydrogenase
THBS2 thrombospondin 2
TLR4 toll-like receptor 4
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPD52 tumor protein D52
TRAPPC6A trafficking protein particle complex 6A
UGDH UDP-glucose 6-dehydrogenase

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANGPT1 angiopoietin 1
AQP3 aquaporin 3 (Gill blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AUTS2 autism susceptibility candidate 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1S complement component 1, s subcomponent
C5 complement component 5
CCNA2 cyclin A2
CCNG2 cyclin G2
CDC42 cell division cycle 42
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPF centromere protein F, 350/400kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHL1 cell adhesion molecule L1-like
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL1A2 collagen, type I, alpha 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL12 chemokine (C-X-C motif) ligand 12
CYTL1 cytokine-like 1
DDIT4 DNA-damage-inducible transcript 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
E2F2 E2F transcription factor 2
EIF5 eukaryotic translation initiation factor 5
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM129A family with sequence similarity 129, member A
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FST follistatin
GLRX glutaredoxin (thioltransferase)
GRB14 growth factor receptor-bound protein 14
GSTZ1 glutathione S-transferase zeta 1
HBD hemoglobin, delta
HMGB2 high mobility group box 2
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOXB2 homeobox B2
HOXC6 homeobox C6
IL1R1 interleukin 1 receptor, type I
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
KIF20A kinesin family member 20A
LINC00341 long intergenic non-protein coding RNA 341
LMO4 LIM domain only 4
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MGST3 microsomal glutathione S-transferase 3
MME membrane metallo-endopeptidase
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NLRP2 NLR family, pyrin domain containing 2
NTS neurotensin
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
PLIN1 perilipin 1
PPAP2B phosphatidic acid phosphatase type 2B
PSRC1 proline/serine-rich coiled-coil 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP4 retinol binding protein 4, plasma
RHOBTB3 Rho-related BTB domain containing 3
S100P S100 calcium binding protein P
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SLC38A2 solute carrier family 38, member 2
SMC4 structural maintenance of chromosomes 4
STEAP1 six transmembrane epithelial antigen of the prostate 1
TCF4 transcription factor 4
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM47 transmembrane protein 47
TOP2A topoisomerase (DNA) II alpha 170kDa
TSC22D3 TSC22 domain family, member 3
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)