BRD-K64642496_-666_VCAP_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-K64642496_-666_VCAP_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCPG1 cell cycle progression 1
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLIC4 chloride intracellular channel 4
COL4A5 collagen, type IV, alpha 5
COPA coatomer protein complex, subunit alpha
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DST dystonin
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FRY furry homolog (Drosophila)
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL13RA1 interleukin 13 receptor, alpha 1
IRS1 insulin receptor substrate 1
JUN jun proto-oncogene
KRT15 keratin 15, type I
LINC00341 long intergenic non-protein coding RNA 341
MARS methionyl-tRNA synthetase
MDFIC MyoD family inhibitor domain containing
MFAP5 microfibrillar associated protein 5
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO1D myosin ID
MYOF myoferlin
NCF2 neutrophil cytosolic factor 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAWR PRKC, apoptosis, WT1, regulator
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLBD1 phospholipase B domain containing 1
PSAT1 phosphoserine aminotransferase 1
PXN paxillin
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100A8 S100 calcium binding protein A8
SARS seryl-tRNA synthetase
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SULF1 sulfatase 1
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TRPS1 trichorhinophalangeal syndrome I
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AHCY adenosylhomocysteinase
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
ATPIF1 ATPase inhibitory factor 1
AURKA aurora kinase A
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIRC5 baculoviral IAP repeat containing 5
BUB3 BUB3 mitotic checkpoint protein
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CBR3 carbonyl reductase 3
CBX3 chromobox homolog 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CKS2 CDC28 protein kinase regulatory subunit 2
DCXR dicarbonyl/L-xylulose reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4E eukaryotic translation initiation factor 4E
FAM111A family with sequence similarity 111, member A
FAS Fas cell surface death receptor
FASTKD5 FAST kinase domains 5
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GTSE1 G-2 and S-phase expressed 1
HIST1H2BK histone cluster 1, H2bk
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA4 heat shock 70kDa protein 4
HSPA8 heat shock 70kDa protein 8
IFI6 interferon, alpha-inducible protein 6
ISG15 ISG15 ubiquitin-like modifier
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIG1 ligase I, DNA, ATP-dependent
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUC7L3 LUC7-like 3 (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MELK maternal embryonic leucine zipper kinase
MYCBP MYC binding protein
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUTF2 nuclear transport factor 2
OLFM1 olfactomedin 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
PPA1 pyrophosphatase (inorganic) 1
PPIG peptidylprolyl isomerase G (cyclophilin G)
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRDX2 peroxiredoxin 2
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PTMA prothymosin, alpha
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTTG1 pituitary tumor-transforming 1
RCC1 regulator of chromosome condensation 1
RPA3 replication protein A3, 14kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
SCAND1 SCAN domain containing 1
SMC4 structural maintenance of chromosomes 4
SMS spermine synthase
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TARP TCR gamma alternate reading frame protein
TMX4 thioredoxin-related transmembrane protein 4
TSPAN8 tetraspanin 8
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2