BRD-K64642496_-666_U937_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K64642496_-666_U937_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMDHD2 amidohydrolase domain containing 2
ANK2 ankyrin 2, neuronal
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
CBS cystathionine-beta-synthase
CGRRF1 cell growth regulator with ring finger domain 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKM creatine kinase, muscle
CLDN10 claudin 10
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
DAPK1 death-associated protein kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EVI2A ecotropic viral integration site 2A
FAM129A family with sequence similarity 129, member A
FXYD1 FXYD domain containing ion transport regulator 1
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GREM1 gremlin 1, DAN family BMP antagonist
GUSB glucuronidase, beta
H2BFS H2B histone family, member S (pseudogene)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
IDO1 indoleamine 2,3-dioxygenase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
ISG15 ISG15 ubiquitin-like modifier
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
KLHL41 kelch-like family member 41
KRT19 keratin 19, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LY6E lymphocyte antigen 6 complex, locus E
MEF2C myocyte enhancer factor 2C
MYL1 myosin, light chain 1, alkali; skeletal, fast
NAP1L3 nucleosome assembly protein 1-like 3
NEB nebulin
NFIL3 nuclear factor, interleukin 3 regulated
NID2 nidogen 2 (osteonidogen)
NLGN4X neuroligin 4, X-linked
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBLD phenazine biosynthesis-like protein domain containing
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PNKP polynucleotide kinase 3'-phosphatase
PNMA2 paraneoplastic Ma antigen 2
PTN pleiotrophin
RHOB ras homolog family member B
RSAD2 radical S-adenosyl methionine domain containing 2
SELENBP1 selenium binding protein 1
TMOD1 tropomodulin 1
TNNC2 troponin C type 2 (fast)
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TTN titin
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACOT9 acyl-CoA thioesterase 9
ACTN1 actinin, alpha 1
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AIM1 absent in melanoma 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BTG2 BTG family, member 2
C2CD2 C2 calcium-dependent domain containing 2
C8ORF4 chromosome 8 open reading frame 4
CALU calumenin
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CERS6 ceramide synthase 6
CES1 carboxylesterase 1
CNOT7 CCR4-NOT transcription complex, subunit 7
CTSB cathepsin B
CTSC cathepsin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYB5A cytochrome b5 type A (microsomal)
CYTL1 cytokine-like 1
DENND2D DENN/MADD domain containing 2D
DUSP4 dual specificity phosphatase 4
EFCAB14 EF-hand calcium binding domain 14
EGR3 early growth response 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
FASTKD5 FAST kinase domains 5
FN1 fibronectin 1
HAL histidine ammonia-lyase
HAT1 histone acetyltransferase 1
HDAC2 histone deacetylase 2
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
IPO7 importin 7
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBR lamin B receptor
LIMS1 LIM and senescent cell antigen-like domains 1
LTB lymphotoxin beta (TNF superfamily, member 3)
MARCKS myristoylated alanine-rich protein kinase C substrate
MEGF9 multiple EGF-like-domains 9
MPHOSPH8 M-phase phosphoprotein 8
MSMB microseminoprotein, beta-
MYC v-myc avian myelocytomatosis viral oncogene homolog
NARFL nuclear prelamin A recognition factor-like
NFIB nuclear factor I/B
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5DC2 5'-nucleotidase domain containing 2
NTS neurotensin
PLAUR plasminogen activator, urokinase receptor
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLLP plasmolipin
PPIF peptidylprolyl isomerase F
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
RAB4A RAB4A, member RAS oncogene family
RBMS1 RNA binding motif, single stranded interacting protein 1
RPL31 ribosomal protein L31
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SORD sorbitol dehydrogenase
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TARP TCR gamma alternate reading frame protein
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM9SF2 transmembrane 9 superfamily member 2
TMCO3 transmembrane and coiled-coil domains 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOX3 TOX high mobility group box family member 3
TRIM14 tripartite motif containing 14
TUBB6 tubulin, beta 6 class V
UBE3C ubiquitin protein ligase E3C
UGCG UDP-glucose ceramide glucosyltransferase
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta