BRD-K64642496_-666_THP1_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-K64642496_-666_THP1_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMDEC1 ADAM-like, decysin 1
ADIRF adipogenesis regulatory factor
AMIGO2 adhesion molecule with Ig-like domain 2
APOLD1 apolipoprotein L domain containing 1
AQP1 aquaporin 1 (Colton blood group)
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CBS cystathionine-beta-synthase
CCL4 chemokine (C-C motif) ligand 4
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD47 CD47 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLC Charcot-Leyden crystal galectin
CLDN3 claudin 3
CLDN7 claudin 7
CLIC4 chloride intracellular channel 4
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CTNND1 catenin (cadherin-associated protein), delta 1
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DPP4 dipeptidyl-peptidase 4
EDN1 endothelin 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EMP1 epithelial membrane protein 1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
FHL1 four and a half LIM domains 1
FLT1 fms-related tyrosine kinase 1
FSD1 fibronectin type III and SPRY domain containing 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAREM GRB2 associated, regulator of MAPK1
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GRIA2 glutamate receptor, ionotropic, AMPA 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
INSM1 insulinoma-associated 1
JMJD1C jumonji domain containing 1C
JUND jun D proto-oncogene
KLHDC2 kelch domain containing 2
KRT18 keratin 18, type I
KRT20 keratin 20, type I
LDB3 LIM domain binding 3
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS4 lectin, galactoside-binding, soluble, 4
LMO3 LIM domain only 3 (rhombotin-like 2)
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MYH11 myosin, heavy chain 11, smooth muscle
NFIL3 nuclear factor, interleukin 3 regulated
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM3 PDZ and LIM domain 3
PELI1 pellino E3 ubiquitin protein ligase 1
PLCB4 phospholipase C, beta 4
PLN phospholamban
PLVAP plasmalemma vesicle associated protein
PNMA2 paraneoplastic Ma antigen 2
PPAP2A phosphatidic acid phosphatase type 2A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRUNE2 prune homolog 2 (Drosophila)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTN1 reticulon 1
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOCS2 suppressor of cytokine signaling 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
TACC2 transforming, acidic coiled-coil containing protein 2
TES testin LIM domain protein
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD2 abhydrolase domain containing 2
ADI1 acireductone dioxygenase 1
ANXA6 annexin A6
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
BIRC5 baculoviral IAP repeat containing 5
CCNE2 cyclin E2
CD151 CD151 molecule (Raph blood group)
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CHL1 cell adhesion molecule L1-like
CHMP7 charged multivesicular body protein 7
CKAP2 cytoskeleton associated protein 2
CNPY3 canopy FGF signaling regulator 3
CTR9 CTR9, Paf1/RNA polymerase II complex component
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DEFB1 defensin, beta 1
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FYB FYN binding protein
GAS1 growth arrest-specific 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLIPR1 GLI pathogenesis-related 1
GRWD1 glutamate-rich WD repeat containing 1
GSTP1 glutathione S-transferase pi 1
ICMT isoprenylcysteine carboxyl methyltransferase
INSIG1 insulin induced gene 1
KCTD12 potassium channel tetramerization domain containing 12
KRT10 keratin 10, type I
KYNU kynureninase
LRRC59 leucine rich repeat containing 59
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP3 latent transforming growth factor beta binding protein 3
LYPLA1 lysophospholipase I
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCM10 minichromosome maintenance complex component 10
MED6 mediator complex subunit 6
MEGF9 multiple EGF-like-domains 9
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NME4 NME/NM23 nucleoside diphosphate kinase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
PCYOX1L prenylcysteine oxidase 1 like
PI3 peptidase inhibitor 3, skin-derived
PLAUR plasminogen activator, urokinase receptor
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PPIF peptidylprolyl isomerase F
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PTDSS1 phosphatidylserine synthase 1
PTGES prostaglandin E synthase
SELL selectin L
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SRPX sushi-repeat containing protein, X-linked
SRSF1 serine/arginine-rich splicing factor 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STK10 serine/threonine kinase 10
TATDN2 TatD DNase domain containing 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAF3IP3 TRAF3 interacting protein 3
UBE3C ubiquitin protein ligase E3C
WIPF1 WAS/WASL interacting protein family, member 1
XPO7 exportin 7