BRD-K64642496_-666_SW948_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K64642496_-666_SW948_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY9 adenylate cyclase 9
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
CA4 carbonic anhydrase IV
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAPG capping protein (actin filament), gelsolin-like
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
CSNK2A2 casein kinase 2, alpha prime polypeptide
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DSP desmoplakin
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
G0S2 G0/G1 switch 2
GAS6 growth arrest-specific 6
GPNMB glycoprotein (transmembrane) nmb
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
ISG15 ISG15 ubiquitin-like modifier
KRT19 keratin 19, type I
LAMP3 lysosomal-associated membrane protein 3
LGALS1 lectin, galactoside-binding, soluble, 1
LOXL1 lysyl oxidase-like 1
LUM lumican
MKNK1 MAP kinase interacting serine/threonine kinase 1
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLAU plasminogen activator, urokinase
PPAP2B phosphatidic acid phosphatase type 2B
PTN pleiotrophin
PXDN peroxidasin
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SPON2 spondin 2, extracellular matrix protein
STC2 stanniocalcin 2
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS2 thrombospondin 2
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a
TSC22D3 TSC22 domain family, member 3
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ACLY ATP citrate lyase
AK1 adenylate kinase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CKS2 CDC28 protein kinase regulatory subunit 2
CSK c-src tyrosine kinase
CSRP1 cysteine and glycine-rich protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CYTL1 cytokine-like 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYNLL1 dynein, light chain, LC8-type 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FGFR4 fibroblast growth factor receptor 4
FOLR1 folate receptor 1 (adult)
GLS glutaminase
GSTP1 glutathione S-transferase pi 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
KIAA0125 KIAA0125
LAPTM4B lysosomal protein transmembrane 4 beta
MAPK13 mitogen-activated protein kinase 13
MARCKSL1 MARCKS-like 1
MET MET proto-oncogene, receptor tyrosine kinase
NAP1L1 nucleosome assembly protein 1-like 1
NUP98 nucleoporin 98kDa
PEBP1 phosphatidylethanolamine binding protein 1
PLK1 polo-like kinase 1
PROM1 prominin 1
PRSS3 protease, serine, 3
RBMS1 RNA binding motif, single stranded interacting protein 1
RFK riboflavin kinase
RPL36 ribosomal protein L36
RPL37A ribosomal protein L37a
SNRPF small nuclear ribonucleoprotein polypeptide F
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TPD52 tumor protein D52
TRAPPC3 trafficking protein particle complex 3
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE2S ubiquitin-conjugating enzyme E2S
VDAC1 voltage-dependent anion channel 1
ZC3H13 zinc finger CCCH-type containing 13