BRD-K64642496_-666_SKM1_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-K64642496_-666_SKM1_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
AUTS2 autism susceptibility candidate 2
BLNK B-cell linker
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CD9 CD9 molecule
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLC Charcot-Leyden crystal galectin
CLDN3 claudin 3
CLIC4 chloride intracellular channel 4
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
CYTIP cytohesin 1 interacting protein
DDIT4 DNA-damage-inducible transcript 4
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EGFR epidermal growth factor receptor
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
EXT1 exostosin glycosyltransferase 1
EZR ezrin
FAM69A family with sequence similarity 69, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FHL1 four and a half LIM domains 1
FSD1 fibronectin type III and SPRY domain containing 1
GADD45A growth arrest and DNA-damage-inducible, alpha
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HPCAL1 hippocalcin-like 1
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IL13RA1 interleukin 13 receptor, alpha 1
INA internexin neuronal intermediate filament protein, alpha
IPO13 importin 13
ITM2C integral membrane protein 2C
IVNS1ABP influenza virus NS1A binding protein
LY6E lymphocyte antigen 6 complex, locus E
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MMP9 matrix metallopeptidase 9
MSMO1 methylsterol monooxygenase 1
MYO1D myosin ID
NPTX2 neuronal pentraxin II
OSBPL10 oxysterol binding protein-like 10
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PLCL1 phospholipase C-like 1
PNKP polynucleotide kinase 3'-phosphatase
PRUNE2 prune homolog 2 (Drosophila)
PXN paxillin
RGCC regulator of cell cycle
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC1 syndecan 1
SGK1 serum/glucocorticoid regulated kinase 1
SHB Src homology 2 domain containing adaptor protein B
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC38A1 solute carrier family 38, member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
STON1 stonin 1
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TMSB15A thymosin beta 15a
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
ADCY7 adenylate cyclase 7
AKAP8 A kinase (PRKA) anchor protein 8
ANXA5 annexin A5
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
C1S complement component 1, s subcomponent
CCNF cyclin F
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHPT1 choline phosphotransferase 1
CTSG cathepsin G
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEFB1 defensin, beta 1
EIF4A3 eukaryotic translation initiation factor 4A3
EIF5B eukaryotic translation initiation factor 5B
EMP3 epithelial membrane protein 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
GADD45B growth arrest and DNA-damage-inducible, beta
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HMGA2 high mobility group AT-hook 2
HSPA1A heat shock 70kDa protein 1A
IRS2 insulin receptor substrate 2
KIF5C kinesin family member 5C
KRT10 keratin 10, type I
KRT17 keratin 17, type I
LAT2 linker for activation of T cells family, member 2
LEPR leptin receptor
LMO2 LIM domain only 2 (rhombotin-like 1)
LPL lipoprotein lipase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAGEA6 melanoma antigen family A6
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MARCKS myristoylated alanine-rich protein kinase C substrate
MGST2 microsomal glutathione S-transferase 2
MRPS30 mitochondrial ribosomal protein S30
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
PCYOX1L prenylcysteine oxidase 1 like
PLAC8 placenta-specific 8
PODXL podocalyxin-like
PRKCD protein kinase C, delta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTX3 pentraxin 3, long
RASA4 RAS p21 protein activator 4
RPS11 ribosomal protein S11
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC43A3 solute carrier family 43, member 3
SORD sorbitol dehydrogenase
SPINK1 serine peptidase inhibitor, Kazal type 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TLR4 toll-like receptor 4
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10