BRD-K64642496_-666_PC3_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K64642496_-666_PC3_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5 arachidonate 5-lipoxygenase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BLNK B-cell linker
BTG1 B-cell translocation gene 1, anti-proliferative
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEP57 centrosomal protein 57kDa
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EREG epiregulin
FLOT1 flotillin 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GREM1 gremlin 1, DAN family BMP antagonist
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
IFRD1 interferon-related developmental regulator 1
IGKV4-1 immunoglobulin kappa variable 4-1
JAG1 jagged 1
KAT6B K(lysine) acetyltransferase 6B
KRT6B keratin 6B, type II
MARS methionyl-tRNA synthetase
MDK midkine (neurite growth-promoting factor 2)
MXI1 MAX interactor 1, dimerization protein
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZRN3 PDZ domain containing ring finger 3
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE4 ribonuclease, RNase A family, 4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SARS seryl-tRNA synthetase
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TPBG trophoblast glycoprotein
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AKAP8 A kinase (PRKA) anchor protein 8
BZW1 basic leucine zipper and W2 domains 1
C1S complement component 1, s subcomponent
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND1 cyclin D1
CDC42 cell division cycle 42
CYR61 cysteine-rich, angiogenic inducer, 61
DEFB1 defensin, beta 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
FN1 fibronectin 1
IGFBP7 insulin-like growth factor binding protein 7
IL1B interleukin 1, beta
IL2RG interleukin 2 receptor, gamma
PCTP phosphatidylcholine transfer protein
RPS11 ribosomal protein S11
S100A10 S100 calcium binding protein A10
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
TMEM100 transmembrane protein 100
TNC tenascin C
TSPAN8 tetraspanin 8
UQCRB ubiquinol-cytochrome c reductase binding protein