BRD-K64642496_-666_NCIH2073_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K64642496_-666_NCIH2073_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AKAP12 A kinase (PRKA) anchor protein 12
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP4 bone morphogenetic protein 4
CARS cysteinyl-tRNA synthetase
CCDC86 coiled-coil domain containing 86
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CKB creatine kinase, brain
CKLF chemokine-like factor
CLDN3 claudin 3
CLGN calmegin
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT4 DNA-damage-inducible transcript 4
FAM129A family with sequence similarity 129, member A
FOLR1 folate receptor 1 (adult)
FRY furry homolog (Drosophila)
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDO1 indoleamine 2,3-dioxygenase 1
IFI6 interferon, alpha-inducible protein 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL2RG interleukin 2 receptor, gamma
KRT23 keratin 23, type I
LARP6 La ribonucleoprotein domain family, member 6
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
MAN1A1 mannosidase, alpha, class 1A, member 1
MARS methionyl-tRNA synthetase
MB myoglobin
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP9 matrix metallopeptidase 9
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYH11 myosin, heavy chain 11, smooth muscle
NFIL3 nuclear factor, interleukin 3 regulated
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCP4 Purkinje cell protein 4
PDGFC platelet derived growth factor C
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PSAT1 phosphoserine aminotransferase 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SARS seryl-tRNA synthetase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
STK26 serine/threonine protein kinase 26
SULF1 sulfatase 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNNT1 troponin T type 1 (skeletal, slow)
TRIB3 tribbles pseudokinase 3
TUSC3 tumor suppressor candidate 3
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZBTB18 zinc finger and BTB domain containing 18
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BZW2 basic leucine zipper and W2 domains 2
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CAST calpastatin
CAV2 caveolin 2
CDC42 cell division cycle 42
CDC42SE1 CDC42 small effector 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CSRP1 cysteine and glycine-rich protein 1
CXADR coxsackie virus and adenovirus receptor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
DSG3 desmoglein 3
EIF4B eukaryotic translation initiation factor 4B
EPHA3 EPH receptor A3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
HMG20B high mobility group 20B
HN1 hematological and neurological expressed 1
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHM immunoglobulin heavy constant mu
KIAA1033 KIAA1033
KRT6B keratin 6B, type II
LAMP1 lysosomal-associated membrane protein 1
LIG1 ligase I, DNA, ATP-dependent
LY6D lymphocyte antigen 6 complex, locus D
MAPK13 mitogen-activated protein kinase 13
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PCDH9 protocadherin 9
PLIN3 perilipin 3
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTPRC protein tyrosine phosphatase, receptor type, C
RHCG Rh family, C glycoprotein
RHOB ras homolog family member B
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
S100A10 S100 calcium binding protein A10
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SFN stratifin
SNRPE small nuclear ribonucleoprotein polypeptide E
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TRIM29 tripartite motif containing 29
TRIP6 thyroid hormone receptor interactor 6
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UQCRH ubiquinol-cytochrome c reductase hinge protein
VGLL4 vestigial-like family member 4