BRD-K64642496_-666_NCIH1836_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-K64642496_-666_NCIH1836_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX6 armadillo repeat containing, X-linked 6
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF5 activating transcription factor 5
ATP9A ATPase, class II, type 9A
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CGRRF1 cell growth regulator with ring finger domain 1
CLIC4 chloride intracellular channel 4
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
EMX2 empty spiracles homeobox 2
EPRS glutamyl-prolyl-tRNA synthetase
ESR1 estrogen receptor 1
FAM129A family with sequence similarity 129, member A
FYN FYN proto-oncogene, Src family tyrosine kinase
GRB10 growth factor receptor-bound protein 10
GSTZ1 glutathione S-transferase zeta 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BK histone cluster 1, H2bk
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
IRS2 insulin receptor substrate 2
LTA4H leukotriene A4 hydrolase
MOCOS molybdenum cofactor sulfurase
MSRB2 methionine sulfoxide reductase B2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
N4BP2L2 NEDD4 binding protein 2-like 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PFKP phosphofructokinase, platelet
PHGDH phosphoglycerate dehydrogenase
PLAT plasminogen activator, tissue
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PSAT1 phosphoserine aminotransferase 1
PXDN peroxidasin
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RIOK3 RIO kinase 3
SARS seryl-tRNA synthetase
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SFRP1 secreted frizzled-related protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC25A46 solute carrier family 25, member 46
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SVIL supervillin
TMEM47 transmembrane protein 47
TPD52L1 tumor protein D52-like 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADGRF5 adhesion G protein-coupled receptor F5
AKAP8 A kinase (PRKA) anchor protein 8
ANGPT2 angiopoietin 2
ANXA1 annexin A1
BCAS1 breast carcinoma amplified sequence 1
BMP2 bone morphogenetic protein 2
BTBD3 BTB (POZ) domain containing 3
CADM1 cell adhesion molecule 1
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
COG7 component of oligomeric golgi complex 7
COL1A1 collagen, type I, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CPE carboxypeptidase E
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPAS1 endothelial PAS domain protein 1
FBLN1 fibulin 1
FERMT1 fermitin family member 1
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FRZB frizzled-related protein
GAL galanin/GMAP prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPM6B glycoprotein M6B
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOPX HOP homeobox
HSPA4 heat shock 70kDa protein 4
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IL27RA interleukin 27 receptor, alpha
IL7R interleukin 7 receptor
ITGAV integrin, alpha V
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LRRC17 leucine rich repeat containing 17
LRRN3 leucine rich repeat neuronal 3
LUM lumican
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MSMB microseminoprotein, beta-
NDNF neuron-derived neurotrophic factor
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
PBX3 pre-B-cell leukemia homeobox 3
PDE4B phosphodiesterase 4B, cAMP-specific
PLLP plasmolipin
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PYCARD PYD and CARD domain containing
RGCC regulator of cell cycle
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFTPA2 surfactant protein A2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOX2 SRY (sex determining region Y)-box 2
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCTA T-cell leukemia translocation altered
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TKTL1 transketolase-like 1
TNS3 tensin 3