BRD-K64642496_-666_MDST8_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-K64642496_-666_MDST8_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BTG3 BTG family, member 3
CAV1 caveolin 1, caveolae protein, 22kDa
CCNG2 cyclin G2
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDND1 claudin domain containing 1
CLIC4 chloride intracellular channel 4
COL8A2 collagen, type VIII, alpha 2
CPB1 carboxypeptidase B1 (tissue)
CRABP2 cellular retinoic acid binding protein 2
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
EAF2 ELL associated factor 2
EIF1 eukaryotic translation initiation factor 1
GAS6 growth arrest-specific 6
GLO1 glyoxalase I
GPM6B glycoprotein M6B
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
KLK5 kallikrein-related peptidase 5
KRT81 keratin 81, type II
LRMP lymphoid-restricted membrane protein
LRRC15 leucine rich repeat containing 15
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MZB1 marginal zone B and B1 cell-specific protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NPTX2 neuronal pentraxin II
PAIP1 poly(A) binding protein interacting protein 1
PERP PERP, TP53 apoptosis effector
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLS3 plastin 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RAI14 retinoic acid induced 14
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
SARS seryl-tRNA synthetase
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC38A1 solute carrier family 38, member 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TES testin LIM domain protein
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TPBG trophoblast glycoprotein
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ALCAM activated leukocyte cell adhesion molecule
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASCL1 achaete-scute family bHLH transcription factor 1
AURKA aurora kinase A
BAD BCL2-associated agonist of cell death
BASP1 brain abundant, membrane attached signal protein 1
BST2 bone marrow stromal cell antigen 2
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CD14 CD14 molecule
CD93 CD93 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHPT1 choline phosphotransferase 1
CPVL carboxypeptidase, vitellogenic-like
CYBB cytochrome b-245, beta polypeptide
CYTL1 cytokine-like 1
DCXR dicarbonyl/L-xylulose reductase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
EFNB2 ephrin-B2
EHD1 EH-domain containing 1
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FAM46A family with sequence similarity 46, member A
FERMT2 fermitin family member 2
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLIPR1 GLI pathogenesis-related 1
GPX3 glutathione peroxidase 3
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HOXC6 homeobox C6
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IRS2 insulin receptor substrate 2
JADE1 jade family PHD finger 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLK11 kallikrein-related peptidase 11
LRRN3 leucine rich repeat neuronal 3
MAGEA3 melanoma antigen family A3
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
NFIB nuclear factor I/B
NMB neuromedin B
NMT2 N-myristoyltransferase 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
PDZK1 PDZ domain containing 1
PEBP1 phosphatidylethanolamine binding protein 1
PLK1 polo-like kinase 1
PPIG peptidylprolyl isomerase G (cyclophilin G)
RGS4 regulator of G-protein signaling 4
RHOBTB3 Rho-related BTB domain containing 3
STC1 stanniocalcin 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGOLN2 trans-golgi network protein 2
TLR4 toll-like receptor 4
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAN versican
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZNF185 zinc finger protein 185 (LIM domain)