BRD-K64642496_-666_JHUEM2_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

167 genes differentially expressed following the BRD-K64642496_-666_JHUEM2_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ARG2 arginase 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
CADM1 cell adhesion molecule 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAST calpastatin
CCND2 cyclin D2
CD38 CD38 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLC Charcot-Leyden crystal galectin
COLEC12 collectin sub-family member 12
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DEPTOR DEP domain containing MTOR-interacting protein
DPYD dihydropyrimidine dehydrogenase
EIF1 eukaryotic translation initiation factor 1
EVI2A ecotropic viral integration site 2A
FAM129A family with sequence similarity 129, member A
FGL2 fibrinogen-like 2
FTH1 ferritin, heavy polypeptide 1
GAGE3 G antigen 3
GBP1 guanylate binding protein 1, interferon-inducible
GNLY granulysin
GRB7 growth factor receptor-bound protein 7
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXB2 homeobox B2
HOXB6 homeobox B6
IDO1 indoleamine 2,3-dioxygenase 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IPO13 importin 13
IRF9 interferon regulatory factor 9
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LRRC15 leucine rich repeat containing 15
LYZ lysozyme
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NPTX2 neuronal pentraxin II
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCP4 Purkinje cell protein 4
PDGFC platelet derived growth factor C
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PMM2 phosphomannomutase 2
QPCT glutaminyl-peptide cyclotransferase
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REG3A regenerating islet-derived 3 alpha
RGCC regulator of cell cycle
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SARS seryl-tRNA synthetase
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHB Src homology 2 domain containing adaptor protein B
SLC38A1 solute carrier family 38, member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SULF1 sulfatase 1
TES testin LIM domain protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TYROBP TYRO protein tyrosine kinase binding protein
WARS tryptophanyl-tRNA synthetase
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
AFG3L2 AFG3-like AAA ATPase 2
AK1 adenylate kinase 1
AQP3 aquaporin 3 (Gill blood group)
ARFIP2 ADP-ribosylation factor interacting protein 2
BST2 bone marrow stromal cell antigen 2
C8ORF4 chromosome 8 open reading frame 4
CCND1 cyclin D1
CD24 CD24 molecule
CDC25A cell division cycle 25A
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHPT1 choline phosphotransferase 1
CLU clusterin
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
DCXR dicarbonyl/L-xylulose reductase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
ECI2 enoyl-CoA delta isomerase 2
EFNB2 ephrin-B2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4A3 eukaryotic translation initiation factor 4A3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FASN fatty acid synthase
FLNA filamin A, alpha
FOLR1 folate receptor 1 (adult)
GMDS GDP-mannose 4,6-dehydratase
GPX3 glutathione peroxidase 3
HN1 hematological and neurological expressed 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
ITGB5 integrin, beta 5
KRT10 keratin 10, type I
KRT14 keratin 14, type I
LEPR leptin receptor
LIG1 ligase I, DNA, ATP-dependent
LPL lipoprotein lipase
LTF lactotransferrin
LYPLA1 lysophospholipase I
MAN2B1 mannosidase, alpha, class 2B, member 1
MRPL12 mitochondrial ribosomal protein L12
MSRB2 methionine sulfoxide reductase B2
MYBPC1 myosin binding protein C, slow type
NFIB nuclear factor I/B
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP62 nucleoporin 62kDa
OXA1L oxidase (cytochrome c) assembly 1-like
PDLIM2 PDZ and LIM domain 2 (mystique)
PEBP1 phosphatidylethanolamine binding protein 1
PIP prolactin-induced protein
PRDX4 peroxiredoxin 4
PROM1 prominin 1
QDPR quinoid dihydropteridine reductase
RAD9A RAD9 homolog A (S. pombe)
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
SACS sacsin molecular chaperone
SET SET nuclear proto-oncogene
SETBP1 SET binding protein 1
SLPI secretory leukocyte peptidase inhibitor
SORBS3 sorbin and SH3 domain containing 3
SPTBN1 spectrin, beta, non-erythrocytic 1
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLE3 transducin-like enhancer of split 3
TMED3 transmembrane emp24 protein transport domain containing 3
TNS1 tensin 1
TSPAN3 tetraspanin 3
TSTA3 tissue specific transplantation antigen P35B
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
VAT1 vesicle amine transport 1
VAV3 vav 3 guanine nucleotide exchange factor