BRD-K64642496_-666_HT29_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

405 genes differentially expressed following the BRD-K64642496_-666_HT29_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACVR1 activin A receptor, type I
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ARF4 ADP-ribosylation factor 4
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA1 carbonic anhydrase I
CARS cysteinyl-tRNA synthetase
CAST calpastatin
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CKAP4 cytoskeleton-associated protein 4
CLIC4 chloride intracellular channel 4
COL5A2 collagen, type V, alpha 2
CREB3L2 cAMP responsive element binding protein 3-like 2
CTH cystathionine gamma-lyase
CTSL cathepsin L
CXCL5 chemokine (C-X-C motif) ligand 5
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
EDN3 endothelin 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FICD FIC domain containing
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FNDC3A fibronectin type III domain containing 3A
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GAB2 GRB2-associated binding protein 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
HBB hemoglobin, beta
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA9 heat shock 70kDa protein 9 (mortalin)
HYOU1 hypoxia up-regulated 1
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFI35 interferon-induced protein 35
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
INHBE inhibin, beta E
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KRT23 keratin 23, type I
KRT81 keratin 81, type II
KYNU kynureninase
LAMB3 laminin, beta 3
LAMP2 lysosomal-associated membrane protein 2
LARP6 La ribonucleoprotein domain family, member 6
LCN2 lipocalin 2
LINC00341 long intergenic non-protein coding RNA 341
LIPA lipase A, lysosomal acid, cholesterol esterase
LMO4 LIM domain only 4
LPAR6 lysophosphatidic acid receptor 6
MAN2A1 mannosidase, alpha, class 2A, member 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MUC5B mucin 5B, oligomeric mucus/gel-forming
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OPTN optineurin
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLSCR1 phospholipid scramblase 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS8 protease, serine, 8
PSAT1 phosphoserine aminotransferase 1
PSENEN presenilin enhancer gamma secretase subunit
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGCC regulator of cell cycle
RHOQ ras homolog family member Q
RIOK3 RIO kinase 3
RSAD2 radical S-adenosyl methionine domain containing 2
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCRG1 stimulator of chondrogenesis 1
SEC24D SEC24 family member D
SEC61B Sec61 beta subunit
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SFRP4 secreted frizzled-related protein 4
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC35B1 solute carrier family 35, member B1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNAI2 snail family zinc finger 2
SPARCL1 SPARC-like 1 (hevin)
SQSTM1 sequestosome 1
SRGN serglycin
SRP19 signal recognition particle 19kDa
SSR4 signal sequence receptor, delta
STAT1 signal transducer and activator of transcription 1, 91kDa
TARS threonyl-tRNA synthetase
TCEA1 transcription elongation factor A (SII), 1
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM39A transmembrane protein 39A
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRAM1 translocation associated membrane protein 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
XAF1 XIAP associated factor 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACYP1 acylphosphatase 1, erythrocyte (common) type
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AURKA aurora kinase A
AURKB aurora kinase B
B3GNT1
BACE2 beta-site APP-cleaving enzyme 2
BARD1 BRCA1 associated RING domain 1
BID BH3 interacting domain death agonist
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BMP4 bone morphogenetic protein 4
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C7 complement component 7
CA9 carbonic anhydrase IX
CBX1 chromobox homolog 1
CCNA2 cyclin A2
CCNE2 cyclin E2
CD8A CD8a molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHEK2 checkpoint kinase 2
CKAP2 cytoskeleton associated protein 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYB5A cytochrome b5 type A (microsomal)
DCK deoxycytidine kinase
DDB2 damage-specific DNA binding protein 2, 48kDa
DEK DEK proto-oncogene
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNA2 DNA replication helicase/nuclease 2
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DTYMK deoxythymidylate kinase (thymidylate kinase)
DUT deoxyuridine triphosphatase
E2F8 E2F transcription factor 8
EXO1 exonuclease 1
EXOSC9 exosome component 9
F2R coagulation factor II (thrombin) receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM111A family with sequence similarity 111, member A
FAM64A family with sequence similarity 64, member A
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FBP1 fructose-1,6-bisphosphatase 1
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GATA2 GATA binding protein 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HELLS helicase, lymphoid-specific
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMGN3 high mobility group nucleosomal binding domain 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPB1 heat shock 27kDa protein 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
LEPR leptin receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MARC1 mitochondrial amidoxime reducing component 1
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NASP nuclear autoantigenic sperm protein (histone-binding)
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUP210 nucleoporin 210kDa
NUP93 nucleoporin 93kDa
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSRC1 proline/serine-rich coiled-coil 1
PTMA prothymosin, alpha
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RAD51 RAD51 recombinase
RELN reelin
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RPA1 replication protein A1, 70kDa
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SAC3D1 SAC3 domain containing 1
SEPT11 septin 11
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPC25 SPC25, NDC80 kinetochore complex component
SRSF1 serine/arginine-rich splicing factor 1
SRSF6 serine/arginine-rich splicing factor 6
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBC1D4 TBC1 domain family, member 4
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TMPO thymopoietin
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIM24 tripartite motif containing 24
TRIP13 thyroid hormone receptor interactor 13
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TTK TTK protein kinase
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UNG uracil-DNA glycosylase
VRK1 vaccinia related kinase 1
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein