BRD-K64642496_-666_HCT116_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K64642496_-666_HCT116_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
ANPEP alanyl (membrane) aminopeptidase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
CD40 CD40 molecule, TNF receptor superfamily member 5
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
COL1A1 collagen, type I, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CST6 cystatin E/M
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
ELANE elastase, neutrophil expressed
EPCAM epithelial cell adhesion molecule
EPRS glutamyl-prolyl-tRNA synthetase
ESRP1 epithelial splicing regulatory protein 1
FGFR2 fibroblast growth factor receptor 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLRX glutaredoxin (thioltransferase)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IQCG IQ motif containing G
KLK6 kallikrein-related peptidase 6
KLK7 kallikrein-related peptidase 7
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LOC100505650 uncharacterized LOC100505650
MAST2 microtubule associated serine/threonine kinase 2
MMP11 matrix metallopeptidase 11
NDN necdin, melanoma antigen (MAGE) family member
NLRP2 NLR family, pyrin domain containing 2
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHGDH phosphoglycerate dehydrogenase
PRSS2 protease, serine, 2 (trypsin 2)
PSAT1 phosphoserine aminotransferase 1
RAB25 RAB25, member RAS oncogene family
RANBP9 RAN binding protein 9
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SH3YL1 SH3 and SYLF domain containing 1
SPATS2L spermatogenesis associated, serine-rich 2-like
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRGN serglycin
SST somatostatin
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACSTD2 tumor-associated calcium signal transducer 2
TCL1A T-cell leukemia/lymphoma 1A
TMEM230 transmembrane protein 230
TNNT1 troponin T type 1 (skeletal, slow)
TPD52 tumor protein D52
VEGFA vascular endothelial growth factor A
VGLL1 vestigial-like family member 1
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AKAP8 A kinase (PRKA) anchor protein 8
ALAS1 5'-aminolevulinate synthase 1
ASCL1 achaete-scute family bHLH transcription factor 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP9A ATPase, class II, type 9A
BIRC5 baculoviral IAP repeat containing 5
CCNE2 cyclin E2
CD52 CD52 molecule
CKB creatine kinase, brain
CLU clusterin
CSRP2 cysteine and glycine-rich protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCLK1 doublecortin-like kinase 1
EIF5A eukaryotic translation initiation factor 5A
FABP1 fatty acid binding protein 1, liver
FERMT2 fermitin family member 2
FHL1 four and a half LIM domains 1
IFRD2 interferon-related developmental regulator 2
IL7R interleukin 7 receptor
JMJD6 jumonji domain containing 6
KTN1 kinectin 1 (kinesin receptor)
MLEC malectin
MXRA7 matrix-remodelling associated 7
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFIB nuclear factor I/B
NKX3-1 NK3 homeobox 1
NUAK1 NUAK family, SNF1-like kinase, 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PNMA2 paraneoplastic Ma antigen 2
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
RAB8A RAB8A, member RAS oncogene family
RB1 retinoblastoma 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRP1B ribosomal RNA processing 1B
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNX7 sorting nexin 7
SOD2 superoxide dismutase 2, mitochondrial
SPEN spen family transcriptional repressor
SPRY2 sprouty homolog 2 (Drosophila)
TMEM176B transmembrane protein 176B
TNPO1 transportin 1
USP1 ubiquitin specific peptidase 1
WASL Wiskott-Aldrich syndrome-like