BRD-K64642496_-666_HCC515_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K64642496_-666_HCC515_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
BASP1 brain abundant, membrane attached signal protein 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN3 claudin 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDIT4 DNA-damage-inducible transcript 4
FOLR1 folate receptor 1 (adult)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
L1CAM L1 cell adhesion molecule
LTF lactotransferrin
MSMO1 methylsterol monooxygenase 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1 PDZ domain containing 1
PSAT1 phosphoserine aminotransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SELENBP1 selenium binding protein 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TFF1 trefoil factor 1
TPD52L1 tumor protein D52-like 1
TXNIP thioredoxin interacting protein
VCAM1 vascular cell adhesion molecule 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AKAP12 A kinase (PRKA) anchor protein 12
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD93 CD93 molecule
CDC25A cell division cycle 25A
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FANCI Fanconi anemia, complementation group I
FBN2 fibrillin 2
FEN1 flap structure-specific endonuclease 1
GBP2 guanylate binding protein 2, interferon-inducible
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
HCAR3 hydroxycarboxylic acid receptor 3
HOXA5 homeobox A5
IL1R1 interleukin 1 receptor, type I
IRS2 insulin receptor substrate 2
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LPL lipoprotein lipase
MCM3 minichromosome maintenance complex component 3
MFAP5 microfibrillar associated protein 5
MSH6 mutS homolog 6
MT1M metallothionein 1M
NID1 nidogen 1
OLFM4 olfactomedin 4
PLS3 plastin 3
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFN stratifin
STON1 stonin 1
TBC1D4 TBC1 domain family, member 4
TBX3 T-box 3
THBS1 thrombospondin 1
THSD7A thrombospondin, type I, domain containing 7A
TYMS thymidylate synthetase
UPK1B uroplakin 1B
VWF von Willebrand factor
XYLT1 xylosyltransferase I
ZDHHC6 zinc finger, DHHC-type containing 6
ZWINT ZW10 interacting kinetochore protein