BRD-K64642496_-666_HA1E_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

203 genes differentially expressed following the BRD-K64642496_-666_HA1E_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AARS alanyl-tRNA synthetase
ALOX5 arachidonate 5-lipoxygenase
AMDHD2 amidohydrolase domain containing 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
C1ORF56 chromosome 1 open reading frame 56
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD200 CD200 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC5 chloride intracellular channel 5
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL8A2 collagen, type VIII, alpha 2
CRABP1 cellular retinoic acid binding protein 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP6 dual specificity phosphatase 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
FKBP4 FK506 binding protein 4, 59kDa
FXYD6 FXYD domain containing ion transport regulator 6
GRB7 growth factor receptor-bound protein 7
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLK10 kallikrein-related peptidase 10
MARS methionyl-tRNA synthetase
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MSLN mesothelin
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5E 5'-nucleotidase, ecto (CD73)
ORC1 origin recognition complex, subunit 1
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTPRK protein tyrosine phosphatase, receptor type, K
RAP1GAP2 RAP1 GTPase activating protein 2
RGCC regulator of cell cycle
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SHB Src homology 2 domain containing adaptor protein B
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNX13 sorting nexin 13
SSPN sarcospan
STC2 stanniocalcin 2
TCEA1 transcription elongation factor A (SII), 1
TESK1 testis-specific kinase 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIB3 tribbles pseudokinase 3
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADI1 acireductone dioxygenase 1
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOC aldolase C, fructose-bisphosphate
AMACR alpha-methylacyl-CoA racemase
AMD1 adenosylmethionine decarboxylase 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BST2 bone marrow stromal cell antigen 2
BZW1 basic leucine zipper and W2 domains 1
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCNF cyclin F
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CD81 CD81 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COL5A1 collagen, type V, alpha 1
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DEFB1 defensin, beta 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DHCR24 24-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ECI2 enoyl-CoA delta isomerase 2
EDNRB endothelin receptor type B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F2R coagulation factor II (thrombin) receptor
FBLN1 fibulin 1
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GPX3 glutathione peroxidase 3
GSTA4 glutathione S-transferase alpha 4
HACD2 3-hydroxyacyl-CoA dehydratase 2
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPB8 heat shock 22kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGSF3 immunoglobulin superfamily, member 3
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
IQGAP2 IQ motif containing GTPase activating protein 2
JARID2 jumonji, AT rich interactive domain 2
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIF20A kinesin family member 20A
KRT10 keratin 10, type I
LAGE3 L antigen family, member 3
LAMP5 lysosomal-associated membrane protein family, member 5
LDLR low density lipoprotein receptor
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIPG lipase, endothelial
LOXL1 lysyl oxidase-like 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
MEIS1 Meis homeobox 1
MSMO1 methylsterol monooxygenase 1
MYLIP myosin regulatory light chain interacting protein
MYLK myosin light chain kinase
NAV3 neuron navigator 3
NPY neuropeptide Y
PDZK1IP1 PDZK1 interacting protein 1
PEBP1 phosphatidylethanolamine binding protein 1
PGM1 phosphoglucomutase 1
PLP1 proteolipid protein 1
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRSS23 protease, serine, 23
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTCH1 patched 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAB9A RAB9A, member RAS oncogene family
RHOB ras homolog family member B
RNF167 ring finger protein 167
RPL37A ribosomal protein L37a
S100A10 S100 calcium binding protein A10
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SKP1 S-phase kinase-associated protein 1
SLC16A4 solute carrier family 16, member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLIT2 slit homolog 2 (Drosophila)
SMS spermine synthase
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SQLE squalene epoxidase
STMN1 stathmin 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM7SF2 transmembrane 7 superfamily member 2
TMEM14A transmembrane protein 14A
TMEM45A transmembrane protein 45A
TNC tenascin C
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
ZCCHC24 zinc finger, CCHC domain containing 24
ZMIZ1 zinc finger, MIZ-type containing 1