BRD-K64642496_-666_AGS_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K64642496_-666_AGS_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACE2 angiotensin I converting enzyme 2
ADD3 adducin 3 (gamma)
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BEX1 brain expressed, X-linked 1
CA2 carbonic anhydrase II
CCL19 chemokine (C-C motif) ligand 19
CCNG2 cyclin G2
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLC Charcot-Leyden crystal galectin
CLDN4 claudin 4
CLIC4 chloride intracellular channel 4
COL3A1 collagen, type III, alpha 1
CTH cystathionine gamma-lyase
CTSG cathepsin G
CTSW cathepsin W
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPHA3 EPH receptor A3
FAM134B family with sequence similarity 134, member B
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GMPR2 guanosine monophosphate reductase 2
GNAS GNAS complex locus
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPM6A glycoprotein M6A
GRB14 growth factor receptor-bound protein 14
GRIA2 glutamate receptor, ionotropic, AMPA 2
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IGKC immunoglobulin kappa constant
JUND jun D proto-oncogene
LGALS1 lectin, galactoside-binding, soluble, 1
LIMCH1 LIM and calponin homology domains 1
LTF lactotransferrin
LXN latexin
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MGP matrix Gla protein
MMP12 matrix metallopeptidase 12
MPO myeloperoxidase
MYO6 myosin VI
NEBL nebulette
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
OAT ornithine aminotransferase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA4 protein disulfide isomerase family A, member 4
PNKP polynucleotide kinase 3'-phosphatase
PON3 paraoxonase 3
PRNP prion protein
PSAT1 phosphoserine aminotransferase 1
PSD3 pleckstrin and Sec7 domain containing 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
REEP1 receptor accessory protein 1
RNF167 ring finger protein 167
RSL24D1 ribosomal L24 domain containing 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPG20 spastic paraplegia 20 (Troyer syndrome)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
SSBP2 single-stranded DNA binding protein 2
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TMED2 transmembrane emp24 domain trafficking protein 2
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TRIM2 tripartite motif containing 2
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VIM vimentin
WIF1 WNT inhibitory factor 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AHNAK2 AHNAK nucleoprotein 2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
BCL6 B-cell CLL/lymphoma 6
BTK Bruton agammaglobulinemia tyrosine kinase
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNF cyclin F
CX3CR1 chemokine (C-X3-C motif) receptor 1
EPAS1 endothelial PAS domain protein 1
GLUL glutamate-ammonia ligase
HAL histidine ammonia-lyase
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLK11 kallikrein-related peptidase 11
LOC100505650 uncharacterized LOC100505650
LPL lipoprotein lipase
LYPD1 LY6/PLAUR domain containing 1
MEIS2 Meis homeobox 2
MMD monocyte to macrophage differentiation-associated
MSLN mesothelin
MUC16 mucin 16, cell surface associated
NBL1 neuroblastoma 1, DAN family BMP antagonist
NGRN neugrin, neurite outgrowth associated
PDZD2 PDZ domain containing 2
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTRF polymerase I and transcript release factor
RBPMS RNA binding protein with multiple splicing
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLPI secretory leukocyte peptidase inhibitor
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SYNGR3 synaptogyrin 3
TAGLN transgelin
TCF3 transcription factor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM164 transmembrane protein 164
TMOD1 tropomodulin 1
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIM29 tripartite motif containing 29
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)