BRD-K64642496_-666_A549_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K64642496_-666_A549_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLIC4 chloride intracellular channel 4
CTH cystathionine gamma-lyase
CTSH cathepsin H
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYTIP cytohesin 1 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
EPRS glutamyl-prolyl-tRNA synthetase
FBP1 fructose-1,6-bisphosphatase 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HNMT histamine N-methyltransferase
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
JCHAIN joining chain of multimeric IgA and IgM
KLF4 Kruppel-like factor 4 (gut)
LDLR low density lipoprotein receptor
LGALS2 lectin, galactoside-binding, soluble, 2
LY6E lymphocyte antigen 6 complex, locus E
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MPO myeloperoxidase
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1X metallothionein 1X
NFIL3 nuclear factor, interleukin 3 regulated
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDIA3 protein disulfide isomerase family A, member 3
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SARS seryl-tRNA synthetase
SCGB1D2 secretoglobin, family 1D, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAI2 snail family zinc finger 2
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TCEA1 transcription elongation factor A (SII), 1
TES testin LIM domain protein
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AK1 adenylate kinase 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CCNF cyclin F
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CRYAB crystallin, alpha B
EFNB2 ephrin-B2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX3 glutathione peroxidase 3
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPB8 heat shock 22kDa protein 8
LAPTM4B lysosomal protein transmembrane 4 beta
MYBPC1 myosin binding protein C, slow type
MYLK myosin light chain kinase
NFIB nuclear factor I/B
NRCAM neuronal cell adhesion molecule
RFC5 replication factor C (activator 1) 5, 36.5kDa
RHOF ras homolog family member F (in filopodia)
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
SLPI secretory leukocyte peptidase inhibitor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM164 transmembrane protein 164