BRD-K64642496_-666_A549_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K64642496_-666_A549_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AREG amphiregulin
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA2 carbonic anhydrase II
CAPN2 calpain 2, (m/II) large subunit
CD44 CD44 molecule (Indian blood group)
CEMIP cell migration inducing protein, hyaluronan binding
CFD complement factor D (adipsin)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLDN7 claudin 7
CLDND1 claudin domain containing 1
COL6A1 collagen, type VI, alpha 1
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHRS7 dehydrogenase/reductase (SDR family) member 7
DUSP6 dual specificity phosphatase 6
EDN3 endothelin 3
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HOMER3 homer scaffolding protein 3
IARS isoleucyl-tRNA synthetase
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IPO13 importin 13
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KRT18 keratin 18, type I
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LGALS3 lectin, galactoside-binding, soluble, 3
MCL1 myeloid cell leukemia 1
MET MET proto-oncogene, receptor tyrosine kinase
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
NEBL nebulette
NPDC1 neural proliferation, differentiation and control, 1
NT5E 5'-nucleotidase, ecto (CD73)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PRNP prion protein
PTN pleiotrophin
PYGB phosphorylase, glycogen; brain
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
S100A14 S100 calcium binding protein A14
SARS seryl-tRNA synthetase
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC38A1 solute carrier family 38, member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
ST18 suppression of tumorigenicity 18, zinc finger
STC2 stanniocalcin 2
STK39 serine threonine kinase 39
SYNJ2 synaptojanin 2
TCEA1 transcription elongation factor A (SII), 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AGR2 anterior gradient 2
AK1 adenylate kinase 1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMACR alpha-methylacyl-CoA racemase
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
C8ORF4 chromosome 8 open reading frame 4
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CXCL5 chemokine (C-X-C motif) ligand 5
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DHCR24 24-dehydrocholesterol reductase
F2R coagulation factor II (thrombin) receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGB fibrinogen beta chain
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
GPX3 glutathione peroxidase 3
GTSE1 G-2 and S-phase expressed 1
HES1 hes family bHLH transcription factor 1
HOXC6 homeobox C6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFBP4 insulin-like growth factor binding protein 4
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KANK2 KN motif and ankyrin repeat domains 2
KIAA0232 KIAA0232
KIF14 kinesin family member 14
LBH limb bud and heart development
MARCKS myristoylated alanine-rich protein kinase C substrate
MEGF9 multiple EGF-like-domains 9
MYCBP MYC binding protein
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY neuropeptide Y
NT5DC2 5'-nucleotidase domain containing 2
NTS neurotensin
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PRSS23 protease, serine, 23
PSPH phosphoserine phosphatase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RBPMS RNA binding protein with multiple splicing
RPL31 ribosomal protein L31
RPS11 ribosomal protein S11
RUNX3 runt-related transcription factor 3
SKP1 S-phase kinase-associated protein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TESC tescalcin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM2 transmembrane protein 2
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TOX3 TOX high mobility group box family member 3
TXNDC9 thioredoxin domain containing 9
UPK1B uroplakin 1B
VAV3 vav 3 guanine nucleotide exchange factor