BRD-K64642496_-666_A375_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

50 genes differentially expressed following the BRD-K64642496_-666_A375_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CARS cysteinyl-tRNA synthetase
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
COL3A1 collagen, type III, alpha 1
CRABP2 cellular retinoic acid binding protein 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GOT1 glutamic-oxaloacetic transaminase 1, soluble
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
MGP matrix Gla protein
MZB1 marginal zone B and B1 cell-specific protein
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PSAT1 phosphoserine aminotransferase 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TARS threonyl-tRNA synthetase
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF5 activating transcription factor 5
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CCND1 cyclin D1
CCNF cyclin F
CTSC cathepsin C
EDNRB endothelin receptor type B
EFNB2 ephrin-B2
PLK1 polo-like kinase 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
STC1 stanniocalcin 1