BRD-K64634304_Retinoic acid_THP1_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K64634304_Retinoic acid_THP1_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADA adenosine deaminase
ADD3 adducin 3 (gamma)
AIF1 allograft inflammatory factor 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMIGO2 adhesion molecule with Ig-like domain 2
BCL2A1 BCL2-related protein A1
CD24 CD24 molecule
CD34 CD34 molecule
CD52 CD52 molecule
CREG1 cellular repressor of E1A-stimulated genes 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYB561 cytochrome b561
CYTH1 cytohesin 1
EIF5 eukaryotic translation initiation factor 5
ELF4 E74-like factor 4 (ets domain transcription factor)
FTH1 ferritin, heavy polypeptide 1
GJA1 gap junction protein, alpha 1, 43kDa
GM2A GM2 ganglioside activator
GNAS GNAS complex locus
GSTP1 glutathione S-transferase pi 1
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa
HDGFRP3 hepatoma-derived growth factor, related protein 3
HMOX1 heme oxygenase 1
HOPX HOP homeobox
ICAM1 intercellular adhesion molecule 1
IFI30 interferon, gamma-inducible protein 30
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGAV integrin, alpha V
JUP junction plakoglobin
KYNU kynureninase
LCK LCK proto-oncogene, Src family tyrosine kinase
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MREG melanoregulin
NCF1C neutrophil cytosolic factor 1C pseudogene
NCOA3 nuclear receptor coactivator 3
NRIP1 nuclear receptor interacting protein 1
NSG1 neuron specific gene family member 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PGD phosphogluconate dehydrogenase
PLAT plasminogen activator, tissue
PSAP prosaposin
QPCT glutaminyl-peptide cyclotransferase
RAB13 RAB13, member RAS oncogene family
RGS5 regulator of G-protein signaling 5
RIT1 Ras-like without CAAX 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMAD3 SMAD family member 3
SNN stannin
STX1A syntaxin 1A (brain)
TIMP3 TIMP metallopeptidase inhibitor 3
TLR4 toll-like receptor 4
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNIP1 TNFAIP3 interacting protein 1
TNNT1 troponin T type 1 (skeletal, slow)
TREM1 triggering receptor expressed on myeloid cells 1
TUSC3 tumor suppressor candidate 3

decreased expression

Symbol Name
AHNAK AHNAK nucleoprotein
AKAP12 A kinase (PRKA) anchor protein 12
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL2 B-cell CLL/lymphoma 2
CCDC86 coiled-coil domain containing 86
CCDC92 coiled-coil domain containing 92
CD44 CD44 molecule (Indian blood group)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CTGF connective tissue growth factor
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ETV5 ets variant 5
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGF13 fibroblast growth factor 13
GAS1 growth arrest-specific 1
HOXA10 homeobox A10
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGFBP7 insulin-like growth factor binding protein 7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INSR insulin receptor
KAZN kazrin, periplakin interacting protein
KDM4B lysine (K)-specific demethylase 4B
KIF5C kinesin family member 5C
LINC00341 long intergenic non-protein coding RNA 341
MAOB monoamine oxidase B
MAPT microtubule-associated protein tau
MEF2C myocyte enhancer factor 2C
MT1E metallothionein 1E
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIB nuclear factor I/B
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOLC1 nucleolar and coiled-body phosphoprotein 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PARM1 prostate androgen-regulated mucin-like protein 1
PDZRN3 PDZ domain containing ring finger 3
PEG3 paternally expressed 3
PER2 period circadian clock 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAGL1 pleiomorphic adenoma gene-like 1
PMP22 peripheral myelin protein 22
PON2 paraoxonase 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PUS7 pseudouridylate synthase 7 (putative)
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SATB2 SATB homeobox 2
SEPT10 septin 10
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP4 secreted frizzled-related protein 4
SH3BP4 SH3-domain binding protein 4
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SORD sorbitol dehydrogenase
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
STEAP3 STEAP family member 3, metalloreductase
TCF4 transcription factor 4
TGFBR3 transforming growth factor, beta receptor III
TMEM106B transmembrane protein 106B
TNS1 tensin 1
TRIB2 tribbles pseudokinase 2
TRIM22 tripartite motif containing 22
TRPS1 trichorhinophalangeal syndrome I
TUBB6 tubulin, beta 6 class V
VTCN1 V-set domain containing T cell activation inhibitor 1
YBX3 Y box binding protein 3
ZBTB16 zinc finger and BTB domain containing 16