BRD-K64634304_Retinoic acid_SKMEL28_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K64634304_Retinoic acid_SKMEL28_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BANK1 B-cell scaffold protein with ankyrin repeats 1
CAST calpastatin
CD40 CD40 molecule, TNF receptor superfamily member 5
COL4A1 collagen, type IV, alpha 1
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CXCL5 chemokine (C-X-C motif) ligand 5
CYBB cytochrome b-245, beta polypeptide
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DLK1 delta-like 1 homolog (Drosophila)
DOK5 docking protein 5
DPYSL3 dihydropyrimidinase-like 3
ELANE elastase, neutrophil expressed
EPAS1 endothelial PAS domain protein 1
FAM198B family with sequence similarity 198, member B
FGFR2 fibroblast growth factor receptor 2
GNLY granulysin
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HYOU1 hypoxia up-regulated 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1R1 interleukin 1 receptor, type I
IPO13 importin 13
KRT19 keratin 19, type I
LOC100272216 uncharacterized LOC100272216
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP2 matrix metallopeptidase 2
MT1M metallothionein 1M
NCAPD2 non-SMC condensin I complex, subunit D2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PAPD7 PAP associated domain containing 7
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE10A phosphodiesterase 10A
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PXDN peroxidasin
RGS5 regulator of G-protein signaling 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TBX3 T-box 3
TGFBI transforming growth factor, beta-induced, 68kDa
TLR4 toll-like receptor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPD52 tumor protein D52
XIST X inactive specific transcript (non-protein coding)
ZHX2 zinc fingers and homeoboxes 2
ZNF117 zinc finger protein 117
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK1 adenylate kinase 1
AREG amphiregulin
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
BST2 bone marrow stromal cell antigen 2
C7 complement component 7
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC11A C-type lectin domain family 11, member A
CTSH cathepsin H
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DUSP10 dual specificity phosphatase 10
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
FABP7 fatty acid binding protein 7, brain
FAM216A family with sequence similarity 216, member A
FOLR1 folate receptor 1 (adult)
FXYD2 FXYD domain containing ion transport regulator 2
FXYD5 FXYD domain containing ion transport regulator 5
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLDC glycine dehydrogenase (decarboxylating)
GRB14 growth factor receptor-bound protein 14
HLF hepatic leukemia factor
HLTF helicase-like transcription factor
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPRT1 hypoxanthine phosphoribosyltransferase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LGALS3 lectin, galactoside-binding, soluble, 3
LPL lipoprotein lipase
LZTFL1 leucine zipper transcription factor-like 1
MATN2 matrilin 2
MBP myelin basic protein
MCOLN1 mucolipin 1
MET MET proto-oncogene, receptor tyrosine kinase
NFIB nuclear factor I/B
NOV nephroblastoma overexpressed
NPY1R neuropeptide Y receptor Y1
NRN1 neuritin 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
PAN2 PAN2 poly(A) specific ribonuclease subunit
PLP1 proteolipid protein 1
PRKCH protein kinase C, eta
PSIP1 PC4 and SFRS1 interacting protein 1
PTER phosphotriesterase related
PTN pleiotrophin
PXMP2 peroxisomal membrane protein 2, 22kDa
RGS1 regulator of G-protein signaling 1
RPIA ribose 5-phosphate isomerase A
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SATB1 SATB homeobox 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLPI secretory leukocyte peptidase inhibitor
SORBS1 sorbin and SH3 domain containing 1
SOX4 SRY (sex determining region Y)-box 4
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNC tenascin C
TSPAN3 tetraspanin 3