BRD-K64634304_Retinoic acid_SKM1_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K64634304_Retinoic acid_SKM1_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM28 ADAM metallopeptidase domain 28
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BAG3 BCL2-associated athanogene 3
BPI bactericidal/permeability-increasing protein
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CAMP cathelicidin antimicrobial peptide
CD38 CD38 molecule
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CPE carboxypeptidase E
CPQ carboxypeptidase Q
CREG1 cellular repressor of E1A-stimulated genes 1
CTSD cathepsin D
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFA4 defensin, alpha 4, corticostatin
DENND1B DENN/MADD domain containing 1B
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP5 dual specificity phosphatase 5
EPCAM epithelial cell adhesion molecule
EPHX2 epoxide hydrolase 2, cytoplasmic
ESR1 estrogen receptor 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GJA1 gap junction protein, alpha 1, 43kDa
GRN granulin
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
H3F3B H3 histone, family 3B (H3.3B)
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI16 interferon, gamma-inducible protein 16
IGFBP5 insulin-like growth factor binding protein 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1R2 interleukin 1 receptor, type II
INHBA inhibin, beta A
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KIF14 kinesin family member 14
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTF lactotransferrin
MGAM maltase-glucoamylase
MMP9 matrix metallopeptidase 9
NCOA3 nuclear receptor coactivator 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDGFC platelet derived growth factor C
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTPRC protein tyrosine phosphatase, receptor type, C
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS2 regulator of G-protein signaling 2
RNF19B ring finger protein 19B
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHB Src homology 2 domain containing adaptor protein B
SLAMF7 SLAM family member 7
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOD2 superoxide dismutase 2, mitochondrial
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB2 tribbles pseudokinase 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
WT1 Wilms tumor 1

decreased expression

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
APOD apolipoprotein D
ASCL1 achaete-scute family bHLH transcription factor 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCDC85B coiled-coil domain containing 85B
CCDC86 coiled-coil domain containing 86
CDC25B cell division cycle 25B
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHPT1 choline phosphotransferase 1
CHSY1 chondroitin sulfate synthase 1
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CYCS cytochrome c, somatic
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DSP desmoplakin
ENOPH1 enolase-phosphatase 1
FAM57A family with sequence similarity 57, member A
GADD45B growth arrest and DNA-damage-inducible, beta
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GTPBP4 GTP binding protein 4
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
LPL lipoprotein lipase
LYPLA1 lysophospholipase I
MAMLD1 mastermind-like domain containing 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MRPL15 mitochondrial ribosomal protein L15
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEBL nebulette
NFIB nuclear factor I/B
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOP16 NOP16 nucleolar protein
NREP neuronal regeneration related protein
PAK1IP1 PAK1 interacting protein 1
PEBP1 phosphatidylethanolamine binding protein 1
PLIN1 perilipin 1
PRR7 proline rich 7 (synaptic)
PTCH1 patched 1
PUS7 pseudouridylate synthase 7 (putative)
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPP40 ribonuclease P/MRP 40kDa subunit
RPS11 ribosomal protein S11
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SORD sorbitol dehydrogenase
SRM spermidine synthase
SRPX sushi-repeat containing protein, X-linked
SYBU syntabulin (syntaxin-interacting)
TARBP1 TAR (HIV-1) RNA binding protein 1
TBX3 T-box 3
TGFBR3 transforming growth factor, beta receptor III
TLR4 toll-like receptor 4
TOX3 TOX high mobility group box family member 3
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WDR12 WD repeat domain 12
WDR3 WD repeat domain 3