BRD-K64634304_Retinoic acid_RKO_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K64634304_Retinoic acid_RKO_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOX2 acyl-CoA oxidase 2, branched chain
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
ATN1 atrophin 1
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
AUTS2 autism susceptibility candidate 2
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BMP4 bone morphogenetic protein 4
C3ORF14 chromosome 3 open reading frame 14
CA12 carbonic anhydrase XII
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CELF2 CUGBP, Elav-like family member 2
CERS6 ceramide synthase 6
CHMP4A charged multivesicular body protein 4A
CRABP2 cellular retinoic acid binding protein 2
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
EMP2 epithelial membrane protein 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV1 ets variant 1
FABP4 fatty acid binding protein 4, adipocyte
FHOD3 formin homology 2 domain containing 3
FST follistatin
FZD7 frizzled class receptor 7
GAS6 growth arrest-specific 6
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
GJA1 gap junction protein, alpha 1, 43kDa
GSE1 Gse1 coiled-coil protein
GSTA1 glutathione S-transferase alpha 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGLV3-19 immunoglobulin lambda variable 3-19
IPO13 importin 13
KCNK3 potassium channel, two pore domain subfamily K, member 3
KRT19 keratin 19, type I
LAMP3 lysosomal-associated membrane protein 3
LGALS3 lectin, galactoside-binding, soluble, 3
MAT2A methionine adenosyltransferase II, alpha
NID1 nidogen 1
NRN1 neuritin 1
PBX1 pre-B-cell leukemia homeobox 1
PEG10 paternally expressed 10
PTGDS prostaglandin D2 synthase 21kDa (brain)
RTN2 reticulon 2
S100A14 S100 calcium binding protein A14
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC38A1 solute carrier family 38, member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPON2 spondin 2, extracellular matrix protein
STAB1 stabilin 1
TFPI2 tissue factor pathway inhibitor 2
TLE2 transducin-like enhancer of split 2
TXNRD1 thioredoxin reductase 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRA3 adhesion G protein-coupled receptor A3
ADGRG6 adhesion G protein-coupled receptor G6
ANKRD10 ankyrin repeat domain 10
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BCL6 B-cell CLL/lymphoma 6
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC86 coiled-coil domain containing 86
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLU clusterin
COL3A1 collagen, type III, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSRP1 cysteine and glycine-rich protein 1
CST3 cystatin C
CXCL13 chemokine (C-X-C motif) ligand 13
CYB5R1 cytochrome b5 reductase 1
DBN1 drebrin 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOLR1 folate receptor 1 (adult)
FXYD5 FXYD domain containing ion transport regulator 5
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LYZ lysozyme
MARCKSL1 MARCKS-like 1
NAV2 neuron navigator 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PEBP1 phosphatidylethanolamine binding protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLSCR3 phospholipid scramblase 3
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PSENEN presenilin enhancer gamma secretase subunit
QDPR quinoid dihydropteridine reductase
RPS21 ribosomal protein S21
SACS sacsin molecular chaperone
SCML1 sex comb on midleg-like 1 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF6 serine/arginine-rich splicing factor 6
STK39 serine threonine kinase 39
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TBCB tubulin folding cofactor B
TEX10 testis expressed 10
TJP2 tight junction protein 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WDR1 WD repeat domain 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon