BRD-K64052750_gefitinib_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K64052750_gefitinib_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADCK3 aarF domain containing kinase 3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CLDN3 claudin 3
COPA coatomer protein complex, subunit alpha
CSF1R colony stimulating factor 1 receptor
DAAM2 dishevelled associated activator of morphogenesis 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DEPTOR DEP domain containing MTOR-interacting protein
DLK1 delta-like 1 homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL1 four and a half LIM domains 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
HCLS1 hematopoietic cell-specific Lyn substrate 1
HSPA2 heat shock 70kDa protein 2
IFITM1 interferon induced transmembrane protein 1
IQGAP1 IQ motif containing GTPase activating protein 1
JADE2 jade family PHD finger 2
LTBP3 latent transforming growth factor beta binding protein 3
MECOM MDS1 and EVI1 complex locus
MFAP5 microfibrillar associated protein 5
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MSLN mesothelin
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MYB v-myb avian myeloblastosis viral oncogene homolog
MYO1D myosin ID
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
ODAM odontogenic, ameloblast asssociated
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLTP phospholipid transfer protein
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB40B RAB40B, member RAS oncogene family
RFTN1 raftlin, lipid raft linker 1
RGS1 regulator of G-protein signaling 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCARB2 scavenger receptor class B, member 2
SDC4 syndecan 4
SESN1 sestrin 1
TF transferrin
TLE2 transducin-like enhancer of split 2
TMPRSS3 transmembrane protease, serine 3
TXNIP thioredoxin interacting protein
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
ZNF652 zinc finger protein 652
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
AURKA aurora kinase A
BTG3 BTG family, member 3
C3ORF14 chromosome 3 open reading frame 14
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPF centromere protein F, 350/400kDa
CSRP2 cysteine and glycine-rich protein 2
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
E2F2 E2F transcription factor 2
EGR2 early growth response 2
FABP7 fatty acid binding protein 7, brain
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GLIPR1 GLI pathogenesis-related 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB2 high mobility group box 2
JAG1 jagged 1
KIF20A kinesin family member 20A
KLF4 Kruppel-like factor 4 (gut)
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT81 keratin 81, type II
KYNU kynureninase
LEF1 lymphoid enhancer-binding factor 1
MELK maternal embryonic leucine zipper kinase
NEK2 NIMA-related kinase 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUSAP1 nucleolar and spindle associated protein 1
ODC1 ornithine decarboxylase 1
PCP4 Purkinje cell protein 4
PDLIM5 PDZ and LIM domain 5
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PTTG1 pituitary tumor-transforming 1
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SEC61G Sec61 gamma subunit
SLPI secretory leukocyte peptidase inhibitor
TGFBI transforming growth factor, beta-induced, 68kDa
TNC tenascin C
TRIB2 tribbles pseudokinase 2
TUBB4B tubulin, beta 4B class IVb
TUSC3 tumor suppressor candidate 3
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)