BRD-K64052750_gefitinib_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K64052750_gefitinib_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADCK3 aarF domain containing kinase 3
CD14 CD14 molecule
CD93 CD93 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLU clusterin
COL5A1 collagen, type V, alpha 1
CREB1 cAMP responsive element binding protein 1
CXCL5 chemokine (C-X-C motif) ligand 5
DMD dystrophin
EIF5A eukaryotic translation initiation factor 5A
FGFR3 fibroblast growth factor receptor 3
HEBP2 heme binding protein 2
HOXB7 homeobox B7
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IQGAP2 IQ motif containing GTPase activating protein 2
LTBP1 latent transforming growth factor beta binding protein 1
METTL7A methyltransferase like 7A
NOTCH1 notch 1
NREP neuronal regeneration related protein
PHACTR2 phosphatase and actin regulator 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
TAGLN transgelin
TMEM47 transmembrane protein 47
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ANK2 ankyrin 2, neuronal
APOE apolipoprotein E
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BMP2 bone morphogenetic protein 2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CDCP1 CUB domain containing protein 1
CLDN4 claudin 4
CTSK cathepsin K
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
CYR61 cysteine-rich, angiogenic inducer, 61
DFNA5 deafness, autosomal dominant 5
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR2 early growth response 2
EGR3 early growth response 3
EPHA2 EPH receptor A2
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
FAM60A family with sequence similarity 60, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GPC3 glypican 3
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGA2 high mobility group AT-hook 2
IER2 immediate early response 2
IER3 immediate early response 3
IL1B interleukin 1, beta
ISG20 interferon stimulated exonuclease gene 20kDa
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JCHAIN joining chain of multimeric IgA and IgM
KCTD5 potassium channel tetramerization domain containing 5
KRT6B keratin 6B, type II
KYNU kynureninase
LDLR low density lipoprotein receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIF leukemia inhibitory factor
LPAR1 lysophosphatidic acid receptor 1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAT2A methionine adenosyltransferase II, alpha
MDK midkine (neurite growth-promoting factor 2)
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PTN pleiotrophin
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFRP1 secreted frizzled-related protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPP1 secreted phosphoprotein 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TFF1 trefoil factor 1
TGFA transforming growth factor, alpha
TNC tenascin C
TPD52 tumor protein D52
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A