BRD-K63712590_N-[4-(4-Methoxy-phenyl)-thiazol-2-yl]-2-(4-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-ylsulfanyl)-acetamide MLS-0425688.0001_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

57 genes differentially expressed following the BRD-K63712590_N-[4-(4-Methoxy-phenyl)-thiazol-2-yl]-2-(4-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-ylsulfanyl)-acetamide MLS-0425688.0001_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARG2 arginase 2
ATP9A ATPase, class II, type 9A
C5AR1 complement component 5a receptor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL20 chemokine (C-C motif) ligand 20
CD93 CD93 molecule
DDIT4 DNA-damage-inducible transcript 4
EGR1 early growth response 1
HOXB2 homeobox B2
HOXB6 homeobox B6
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
JAG1 jagged 1
KRT18 keratin 18, type I
LAPTM4B lysosomal protein transmembrane 4 beta
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MSLN mesothelin
MT1E metallothionein 1E
NELL2 NEL-like 2 (chicken)
NPTX2 neuronal pentraxin II
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PSPH phosphoserine phosphatase
PTPRK protein tyrosine phosphatase, receptor type, K
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SDC4 syndecan 4
SH2B3 SH2B adaptor protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TPM4 tropomyosin 4
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AP2B1 adaptor-related protein complex 2, beta 1 subunit
CA12 carbonic anhydrase XII
COCH cochlin
FBXL12 F-box and leucine-rich repeat protein 12
FOLR1 folate receptor 1 (adult)
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
MAP7 microtubule-associated protein 7
MYB v-myb avian myeloblastosis viral oncogene homolog
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NRIP1 nuclear receptor interacting protein 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PTER phosphotriesterase related
RCAN1 regulator of calcineurin 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TPBG trophoblast glycoprotein