BRD-K63511615_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

65 genes differentially expressed following the BRD-K63511615_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM8 ADAM metallopeptidase domain 8
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADIRF adipogenesis regulatory factor
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
BMP4 bone morphogenetic protein 4
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRYAB crystallin, alpha B
CST6 cystatin E/M
CXCL14 chemokine (C-X-C motif) ligand 14
EGR1 early growth response 1
GAL galanin/GMAP prepropeptide
GPX3 glutathione peroxidase 3
GREM1 gremlin 1, DAN family BMP antagonist
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
IER3 immediate early response 3
LTBP3 latent transforming growth factor beta binding protein 3
LY6D lymphocyte antigen 6 complex, locus D
MAB21L2 mab-21-like 2 (C. elegans)
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MBNL2 muscleblind-like splicing regulator 2
MXRA8 matrix-remodelling associated 8
OLFML3 olfactomedin-like 3
PDLIM4 PDZ and LIM domain 4
PITX1 paired-like homeodomain 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC38A1 solute carrier family 38, member 1
SLURP1 secreted LY6/PLAUR domain containing 1
STK38L serine/threonine kinase 38 like
TIMP3 TIMP metallopeptidase inhibitor 3
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
VEGFA vascular endothelial growth factor A
YBX3 Y box binding protein 3
ZBTB18 zinc finger and BTB domain containing 18
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AP2B1 adaptor-related protein complex 2, beta 1 subunit
BTBD3 BTB (POZ) domain containing 3
COL4A6 collagen, type IV, alpha 6
COL7A1 collagen, type VII, alpha 1
DMD dystrophin
EIF5 eukaryotic translation initiation factor 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
NOTCH2 notch 2
NPTX2 neuronal pentraxin II
NR2F1 nuclear receptor subfamily 2, group F, member 1
PDLIM1 PDZ and LIM domain 1
PIP prolactin-induced protein
PON2 paraoxonase 2
RAE1 ribonucleic acid export 1
RBM8A RNA binding motif protein 8A
SPON1 spondin 1, extracellular matrix protein
TARDBP TAR DNA binding protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
WNT5A wingless-type MMTV integration site family, member 5A