BRD-K63239300_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K63239300_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM2 absent in melanoma 2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA9 carbonic anhydrase IX
CAV2 caveolin 2
CBX1 chromobox homolog 1
CCNA1 cyclin A1
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL4A2 collagen, type IV, alpha 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
EBI3 Epstein-Barr virus induced 3
EGLN3 egl-9 family hypoxia-inducible factor 3
EPN2 epsin 2
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GPM6A glycoprotein M6A
GSTP1 glutathione S-transferase pi 1
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDO1 indoleamine 2,3-dioxygenase 1
KLK11 kallikrein-related peptidase 11
KLK3 kallikrein-related peptidase 3
LAMP3 lysosomal-associated membrane protein 3
MAP7 microtubule-associated protein 7
MTSS1 metastasis suppressor 1
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NMU neuromedin U
NR1H2 nuclear receptor subfamily 1, group H, member 2
PAEP progestagen-associated endometrial protein
PFKP phosphofructokinase, platelet
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RGS1 regulator of G-protein signaling 1
RGS17 regulator of G-protein signaling 17
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TREM2 triggering receptor expressed on myeloid cells 2
VSIG4 V-set and immunoglobulin domain containing 4
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACSL5 acyl-CoA synthetase long-chain family member 5
ADD3 adducin 3 (gamma)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BEX1 brain expressed, X-linked 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLK1 delta-like 1 homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
FABP1 fatty acid binding protein 1, liver
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GOLGA8A golgin A8 family, member A
HOXC6 homeobox C6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
KRT19 keratin 19, type I
LDLR low density lipoprotein receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMCD1 LIM and cysteine-rich domains 1
MAGEA3 melanoma antigen family A3
MMP11 matrix metallopeptidase 11
MXRA8 matrix-remodelling associated 8
MYO1B myosin IB
OLFM4 olfactomedin 4
OLFML3 olfactomedin-like 3
OSBPL8 oxysterol binding protein-like 8
PCOLCE procollagen C-endopeptidase enhancer
PER2 period circadian clock 2
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PPIF peptidylprolyl isomerase F
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRKCA protein kinase C, alpha
QPRT quinolinate phosphoribosyltransferase
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
THBS1 thrombospondin 1
TMEM97 transmembrane protein 97
TSPAN7 tetraspanin 7
TSPYL5 TSPY-like 5
VCAN versican