BRD-K63195589_Tipifarnib-P1_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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52 genes differentially expressed following the BRD-K63195589_Tipifarnib-P1_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGAP29 Rho GTPase activating protein 29
C1ORF54 chromosome 1 open reading frame 54
CA2 carbonic anhydrase II
CAPG capping protein (actin filament), gelsolin-like
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRABP2 cellular retinoic acid binding protein 2
FGL2 fibrinogen-like 2
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOPX HOP homeobox
IRF8 interferon regulatory factor 8
KCTD12 potassium channel tetramerization domain containing 12
LST1 leukocyte specific transcript 1
MT1E metallothionein 1E
NR2F2 nuclear receptor subfamily 2, group F, member 2
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RAP1GAP2 RAP1 GTPase activating protein 2
RGS4 regulator of G-protein signaling 4
RTN1 reticulon 1
SYT1 synaptotagmin I
TRD T cell receptor delta locus

decreased expression

Symbol Name
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL2 chemokine (C-C motif) ligand 2
CFLAR CASP8 and FADD-like apoptosis regulator
FKBP14 FK506 binding protein 14, 22 kDa
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GUSBP3 glucuronidase, beta pseudogene 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
KLK11 kallikrein-related peptidase 11
LAGE3 L antigen family, member 3
MX2 MX dynamin-like GTPase 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PDGFC platelet derived growth factor C
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
RCAN1 regulator of calcineurin 1
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SPAG4 sperm associated antigen 4
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNC tenascin C
WNT5A wingless-type MMTV integration site family, member 5A