BRD-K63150726_JTE 907_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K63150726_JTE 907_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AREG amphiregulin
ASMTL acetylserotonin O-methyltransferase-like
ASS1 argininosuccinate synthase 1
BIRC3 baculoviral IAP repeat containing 3
CCL20 chemokine (C-C motif) ligand 20
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFD complement factor D (adipsin)
CRELD2 cysteine-rich with EGF-like domains 2
CTSD cathepsin D
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DNTT DNA nucleotidylexotransferase
FKBP14 FK506 binding protein 14, 22 kDa
FKBP5 FK506 binding protein 5
FXYD2 FXYD domain containing ion transport regulator 2
GLRX glutaredoxin (thioltransferase)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HYOU1 hypoxia up-regulated 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
LCN2 lipocalin 2
LGALS4 lectin, galactoside-binding, soluble, 4
MAOA monoamine oxidase A
MBNL2 muscleblind-like splicing regulator 2
MPO myeloperoxidase
MUC1 mucin 1, cell surface associated
NEB nebulin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
ORM1 orosomucoid 1
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PROM1 prominin 1
PRR15L proline rich 15-like
PYCR1 pyrroline-5-carboxylate reductase 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGCC regulator of cell cycle
RHOB ras homolog family member B
RRAD Ras-related associated with diabetes
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SIK1 salt-inducible kinase 1
SLPI secretory leukocyte peptidase inhibitor
SPINK1 serine peptidase inhibitor, Kazal type 1
SRGN serglycin
SRPRB signal recognition particle receptor, B subunit
SSR1 signal sequence receptor, alpha
STEAP1 six transmembrane epithelial antigen of the prostate 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TSC22D3 TSC22 domain family, member 3
VNN1 vanin 1
ZBTB16 zinc finger and BTB domain containing 16
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARL4C ADP-ribosylation factor-like 4C
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AXL AXL receptor tyrosine kinase
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CD44 CD44 molecule (Indian blood group)
CLEC2B C-type lectin domain family 2, member B
CNN3 calponin 3, acidic
COL15A1 collagen, type XV, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNM1 dynamin 1
DST dystonin
DUSP4 dual specificity phosphatase 4
DUT deoxyuridine triphosphatase
EHBP1 EH domain binding protein 1
ETV5 ets variant 5
FAM129A family with sequence similarity 129, member A
FGF13 fibroblast growth factor 13
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
FZD7 frizzled class receptor 7
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GNAS GNAS complex locus
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPNMB glycoprotein (transmembrane) nmb
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
ITGA6 integrin, alpha 6
KRT6B keratin 6B, type II
LEF1 lymphoid enhancer-binding factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
LOXL2 lysyl oxidase-like 2
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP1B microtubule-associated protein 1B
MEIS2 Meis homeobox 2
MMP12 matrix metallopeptidase 12
MTCL1 microtubule crosslinking factor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NPTX1 neuronal pentraxin I
NPY neuropeptide Y
NRCAM neuronal cell adhesion molecule
NTS neurotensin
PHACTR2 phosphatase and actin regulator 2
PTN pleiotrophin
RAD23B RAD23 homolog B (S. cerevisiae)
RAP1GAP RAP1 GTPase activating protein
REEP1 receptor accessory protein 1
RND3 Rho family GTPase 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMAGP small cell adhesion glycoprotein
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPTBN1 spectrin, beta, non-erythrocytic 1
SV2B synaptic vesicle glycoprotein 2B
SYNJ2 synaptojanin 2
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a
TNC tenascin C
TPD52L1 tumor protein D52-like 1
TPM1 tropomyosin 1 (alpha)
TRIP6 thyroid hormone receptor interactor 6
TUBA1A tubulin, alpha 1a
TUBB2B tubulin, beta 2B class IIb