BRD-K63068307_ZSTK-474_HT29_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

262 genes differentially expressed following the BRD-K63068307_ZSTK-474_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADIRF adipogenesis regulatory factor
AGTR1 angiotensin II receptor, type 1
AHNAK AHNAK nucleoprotein
AHR aryl hydrocarbon receptor
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
ARMCX1 armadillo repeat containing, X-linked 1
ATP10A ATPase, class V, type 10A
ATP9A ATPase, class II, type 9A
BACE2 beta-site APP-cleaving enzyme 2
BHLHE41 basic helix-loop-helix family, member e41
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1ORF115 chromosome 1 open reading frame 115
C6ORF48 chromosome 6 open reading frame 48
CCNG1 cyclin G1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFB complement factor B
CHPT1 choline phosphotransferase 1
CLDN10 claudin 10
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
CREB3L1 cAMP responsive element binding protein 3-like 1
CRISP3 cysteine-rich secretory protein 3
CST1 cystatin SN
CST3 cystatin C
CTGF connective tissue growth factor
CTSH cathepsin H
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPP4 dipeptidyl-peptidase 4
DST dystonin
DYNLT3 dynein, light chain, Tctex-type 3
EDN1 endothelin 1
EIF4A2 eukaryotic translation initiation factor 4A2
EIF4B eukaryotic translation initiation factor 4B
ERBB3 erb-b2 receptor tyrosine kinase 3
FADS1 fatty acid desaturase 1
FAM149A family with sequence similarity 149, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FOXO4 forkhead box O4
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA2 GATA binding protein 2
GLS glutaminase
GNB5 guanine nucleotide binding protein (G protein), beta 5
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST3H2A histone cluster 3, H2a
HNMT histamine N-methyltransferase
HOXC6 homeobox C6
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS2 insulin receptor substrate 2
LDLR low density lipoprotein receptor
LEPROT leptin receptor overlapping transcript
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS8 lectin, galactoside-binding, soluble, 8
LINC00342 long intergenic non-protein coding RNA 342
LPPR4 lipid phosphate phosphatase-related protein type 4
LRP10 low density lipoprotein receptor-related protein 10
LXN latexin
MACF1 microtubule-actin crosslinking factor 1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED1 melanoma antigen family D1
MAMLD1 mastermind-like domain containing 1
MBNL2 muscleblind-like splicing regulator 2
MDK midkine (neurite growth-promoting factor 2)
MLPH melanophilin
MSMB microseminoprotein, beta-
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MVP major vault protein
NBR1 neighbor of BRCA1 gene 1
NOV nephroblastoma overexpressed
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFC platelet derived growth factor C
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDZK1IP1 PDZK1 interacting protein 1
PINK1 PTEN induced putative kinase 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2A phosphatidic acid phosphatase type 2A
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTEN phosphatase and tensin homolog
PYCARD PYD and CARD domain containing
QARS glutaminyl-tRNA synthetase
QPCT glutaminyl-peptide cyclotransferase
R3HDM2 R3H domain containing 2
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REG1A regenerating islet-derived 1 alpha
RPL39L ribosomal protein L39-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGC Ras-related GTP binding C
RSRP1 arginine/serine-rich protein 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFXN3 sideroflexin 3
SGK1 serum/glucocorticoid regulated kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35E2B solute carrier family 35, member E2B
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC44A4 solute carrier family 44, member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SQSTM1 sequestosome 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STXBP1 syntaxin binding protein 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMC5 transmembrane channel-like 5
TMEM30B transmembrane protein 30B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TSPAN1 tetraspanin 1
TSPYL5 TSPY-like 5
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
AK4 adenylate kinase 4
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
AURKA aurora kinase A
AURKB aurora kinase B
BARD1 BRCA1 associated RING domain 1
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNF cyclin F
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CENPA centromere protein A
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COL4A6 collagen, type IV, alpha 6
COL5A1 collagen, type V, alpha 1
CPE carboxypeptidase E
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP2 cysteine and glycine-rich protein 2
CXCL13 chemokine (C-X-C motif) ligand 13
DBF4 DBF4 zinc finger
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FEN1 flap structure-specific endonuclease 1
FGFBP1 fibroblast growth factor binding protein 1
FGFR3 fibroblast growth factor receptor 3
FKBP5 FK506 binding protein 5
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPRC5A G protein-coupled receptor, class C, group 5, member A
H2AFX H2A histone family, member X
HAL histidine ammonia-lyase
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGB2 high mobility group box 2
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
IL1RN interleukin 1 receptor antagonist
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB2 lamin B2
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCL1 myeloid cell leukemia 1
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MMP9 matrix metallopeptidase 9
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NME1 NME/NM23 nucleoside diphosphate kinase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PPAT phosphoribosyl pyrophosphate amidotransferase
PSPH phosphoserine phosphatase
RDX radixin
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SMAD1 SMAD family member 1
SPAG5 sperm associated antigen 5
SPARCL1 SPARC-like 1 (hevin)
SPC25 SPC25, NDC80 kinetochore complex component
SPINK5 serine peptidase inhibitor, Kazal type 5
SRM spermidine synthase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TDO2 tryptophan 2,3-dioxygenase
TES testin LIM domain protein
TIGAR TP53 induced glycolysis regulatory phosphatase
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein