BRD-K63068307_ZSTK-474_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

196 genes differentially expressed following the BRD-K63068307_ZSTK-474_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMPD3 adenosine monophosphate deaminase 3
ANKRD36B ankyrin repeat domain 36B
AREG amphiregulin
ARID5B AT rich interactive domain 5B (MRF1-like)
ASXL2 additional sex combs like transcriptional regulator 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCNG2 cyclin G2
CD14 CD14 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
CHIC2 cysteine-rich hydrophobic domain 2
CHMP4A charged multivesicular body protein 4A
CRABP1 cellular retinoic acid binding protein 1
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DEPTOR DEP domain containing MTOR-interacting protein
DIAPH2 diaphanous-related formin 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
DST dystonin
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM8A1 family with sequence similarity 8, member A1
FGF13 fibroblast growth factor 13
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
G0S2 G0/G1 switch 2
GAS6 growth arrest-specific 6
GLRX glutaredoxin (thioltransferase)
GRN granulin
GSE1 Gse1 coiled-coil protein
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMGA2 high mobility group AT-hook 2
HMGN4 high mobility group nucleosomal binding domain 4
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGBP1 immunoglobulin (CD79A) binding protein 1
IL1B interleukin 1, beta
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITM2B integral membrane protein 2B
JAG1 jagged 1
KIAA0355 KIAA0355
KIZ kizuna centrosomal protein
KLHL24 kelch-like family member 24
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LETMD1 LETM1 domain containing 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LINC00341 long intergenic non-protein coding RNA 341
LOC100272216 uncharacterized LOC100272216
LXN latexin
MAGEA3 melanoma antigen family A3
MFGE8 milk fat globule-EGF factor 8 protein
MIR22HG MIR22 host gene
MTSS1 metastasis suppressor 1
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NCOA3 nuclear receptor coactivator 3
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NOTCH2NL notch 2 N-terminal like
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PERP PERP, TP53 apoptosis effector
PGAP1 post-GPI attachment to proteins 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNRC1 proline-rich nuclear receptor coactivator 1
RPL31 ribosomal protein L31
RPS11 ribosomal protein S11
S100A12 S100 calcium binding protein A12
SATB1 SATB homeobox 1
SCD5 stearoyl-CoA desaturase 5
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A2 solute carrier family 38, member 2
SOX4 SRY (sex determining region Y)-box 4
SPRY4 sprouty homolog 4 (Drosophila)
SULF1 sulfatase 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VCAN versican
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
YPEL5 yippee-like 5 (Drosophila)
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF277 zinc finger protein 277
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
AK4 adenylate kinase 4
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1ORF112 chromosome 1 open reading frame 112
CCND3 cyclin D3
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CYB5A cytochrome b5 type A (microsomal)
DCK deoxycytidine kinase
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELAVL1 ELAV like RNA binding protein 1
ENO1 enolase 1, (alpha)
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
GALE UDP-galactose-4-epimerase
GDF15 growth differentiation factor 15
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GOLM1 golgi membrane protein 1
GSTM3 glutathione S-transferase mu 3 (brain)
HAT1 histone acetyltransferase 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
LMNB1 lamin B1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NDC1 NDC1 transmembrane nucleoporin
NET1 neuroepithelial cell transforming 1
P3H2 prolyl 3-hydroxylase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PEX11A peroxisomal biogenesis factor 11 alpha
PGC progastricsin (pepsinogen C)
PHGDH phosphoglycerate dehydrogenase
PITX1 paired-like homeodomain 1
PLAC8 placenta-specific 8
PNP purine nucleoside phosphorylase
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRDX1 peroxiredoxin 1
PSAT1 phosphoserine aminotransferase 1
PSMC3IP PSMC3 interacting protein
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RGS1 regulator of G-protein signaling 1
RNASEH2A ribonuclease H2, subunit A
RPN2 ribophorin II
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SHCBP1 SHC SH2-domain binding protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPATS2L spermatogenesis associated, serine-rich 2-like
SPP1 secreted phosphoprotein 1
STIP1 stress-induced phosphoprotein 1
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TUBA4A tubulin, alpha 4a
TUBG1 tubulin, gamma 1
YARS tyrosyl-tRNA synthetase
ZWINT ZW10 interacting kinetochore protein